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EC number: 205-293-0 | CAS number: 137-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from handbook.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Chapter 107 – Metam-Sodium
- Author:
- Robert Krieger
- Year:
- 2 010
- Bibliographic source:
- Hayes' Handbook of Pesticide Toxicology (Third Edition), 2010, Pages 2293–2306
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity of Metam-sodium (CAS no: 137-42-8) in rat
- Author:
- Anna Wypych, George Wypych
- Year:
- 2 015
- Bibliographic source:
- Databook of Biocides, 2015
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity of Metam-sodium (CAS no: 137-42-8) in rat.
- Author:
- George Wypych, Anna Wypych
- Year:
- 2 015
- Bibliographic source:
- Databook of Preservatives, 2015.
- Reference Type:
- secondary source
- Title:
- Conclusion regarding the peer review of the pesticide risk assessment of the active substance metam.
- Author:
- European Food Safety Authority (EFSA)
- Year:
- 2 008
- Bibliographic source:
- EFSA Scientific Report (2008) 203, 1-97.
- Reference Type:
- secondary source
- Title:
- US EPA-Pesticides; Metam-sodium, US EPA ARCHIVE DOCUMENT
- Author:
- US EPA
- Year:
- 1 994
- Bibliographic source:
- US EPA-Pesticides; Metam-sodium, US EPA ARCHIVE DOCUMENT, US EPA, 1994
- Reference Type:
- secondary source
- Title:
- US EPA-Pesticides; Metam-sodium
- Author:
- US EPA; Office of Pesticide Programs
- Year:
- 1 993
- Bibliographic source:
- US EPA-Pesticides; Metam-sodium, US EPA; Office of Pesticide Programs, 1993
- Reference Type:
- secondary source
- Title:
- Draft Assessment Report (Metam-sodium), ANNEX B.6 Toxicology and metabolism
- Author:
- European Food Safety Authority (EFSA)
- Year:
- 2 007
- Bibliographic source:
- Draft Assessment Report (Metam-sodium) - Volume 3, Annex B, part 2, B.6, October 2007.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of Metam-sodium (CAS no: 137-42-8) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Metam-sodium
- EC Number:
- 205-293-0
- EC Name:
- Metam-sodium
- Cas Number:
- 137-42-8
- Molecular formula:
- C2H5NS2.Na
- IUPAC Name:
- sodium (methylcarbamothioyl)sulfanide
- Details on test material:
- - IUPAC Name: Metam-sodium
- InChI: 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Smiles: C(=S)(NC)[S-].[Na+]
- Molecular formula :C2H4NNaS2
- Molecular weight:129.1826 g/mol
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: Metam-sodium
- InChI: 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Smiles: C(=S)(NC)[S-].[Na+]
- Molecular formula :C2H4NNaS2
- Molecular weight:129.1826 g/mol
- Substance type:Organic
Test animals
- Species:
- rat
- Strain:
- other: CD rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- not specified
- Doses:
- 640, 800, 1000 or 1600 mg/kg bw
- No. of animals per sex per dose:
- Total = 40 (Sex/dose)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed for mortality and clinical signs.
- Necropsy of survivors performed: yes - Statistics:
- The data obtained did not permit the fitting of a probit line using the standard method. However, it was possible to fit a line if a fixed slope was assumed and a value of 8.333 was used.
Results and discussion
- Preliminary study:
- A preliminary test was carried out by dosing 2 rats/sex at 1000 mg/kg bw and the acute median lethal dose of metam sodium was in the region of 1000 mg/kg be for males and >1000 mg/kg bw for female rats.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 896 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 779 - 1 031
- Remarks on result:
- other: 50% mortality was observed
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 870 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 715 - 1 059
- Remarks on result:
- other: 50% mortality was observed
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 924 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 758 - 1 130
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed as below –
Male and female rats combined 896 mg/kg bw, with 95% confidence limit of 779-1031 mg/kg bw.
Males only: 870 mg/kg bw, with 95% confidence limit of 715-1059 mg/kg bw.
Females only: 924 mg/kg bw, with 95% confidence limit of 758-1130 mg/kg bw. - Clinical signs:
- other: All animals had piloerection, hunched posture, abnormal gait, lethargy, decreased respiratory rate, ptosis, pallor of the extremities, increased salivation. Clonic convulsions and prostration affected animals at 1000 and 1600 mg/kg bw.
- Gross pathology:
- No macroscopic abnormalities were seen.
- Other findings:
- not specified
Any other information on results incl. tables
Table - Mortality:
Dose (mg/kg bw) |
Death |
Day or hours after dosing |
||
|
M |
F |
M |
F |
640 |
0 |
0 |
|
|
800 |
1 |
0 |
Day 2 |
|
1000 |
5 |
5 |
4 day 4, 1 after 5 h |
4 day 2, 1 after 5 h |
1600 |
5 |
5 |
4 after 4 h; 1 after 1 h |
3 after 4 h; 2 after 5 h |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 value was considered as follows –
Male and female rats - 896 mg/kg bw, with 95% confidence limit of 779-1031 mg/kg bw; Male rats - 870 mg/kg bw, with 95% confidence limit of 715-1059 mg/kg bw; and Female rats - 924 mg/kg bw, with 95% confidence limit of 758-1130 mg/kg bw, when male and female CD rats were treated with Metam-sodium (CAS no: 137-42-8) via oral route. - Executive summary:
Acute oral toxicity study of Metam-sodium (CAS no: 137-42-8)was conducted in 40 male and female CD rats at the concentration of 640, 800, 1000 or 1600 mg/kg bw. All animals received metam sodium (510 g/L) via oral gavage route. A preliminary test was carried out by dosing 2 rats/sex at 1000 mg/kg bw and the acute median lethal dose of metam sodium was in the region of 1000 mg/kg be for males and >1000 mg/kg bw for female rats. The data obtained did not permit the fitting of a probit line using the standard method. However, it was possible to fit a line if a fixed slope was assumed and a value of 8.333 was used.The animals were observed for mortality and clinical signs for 14 days. Necropsy was performed. 50% mortality was observed as– Male and female rats combined 896 mg/kg bw; Males only: 870 mg/kg bw; Females only: 924 mg/kg bw. All animals had piloerection, hunched posture, abnormal gait, lethargy, decreased respiratory rate, ptosis, pallor of the extremities, increased salivation. Clonic convulsions and prostration affected animals at 1000 and 1600 mg/kg bw. Body weight was not affected in surviving male animals; surviving females of the group 800 mg/kg bw had decreased body weight. No macroscopic abnormalities were seen. Therefore, LD50 was considered to be 896 mg/kg bw in Male and female rats; 870 mg/kg bw in Male rats and 924 mg/kg bw in Female rats, when male and female CD rats were treated with Metam-sodium (CAS no: 137-42-8) via oral route.
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