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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 04/June/2016 to 06/June/2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Key result
Temp.:
20 °C
Vapour pressure:
0.135 Pa
Key result
Temp.:
25 °C
Vapour pressure:
0.208 Pa

The following vapour pressures were determined experimentally and considered as valid (mean and standard deviation given):

Experimentally Determined Vapour Pressures:

T

T

P

Stand. Dev. P

RSD P

°C

K

Pa

Pa

%

30.0

303.2

3.16E-01

1.95E-02

6.2%

40.0

313.2

7.12E-01

3.75E-02

5.3%

50.0

323.2

1.49E+00

1.30E-01

8.8%

In this table, E-0X resp. E+0X represents multiplication with 10-Xresp. 10+X.

Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation

 

For the test itemSandalmysore Core, the following vapour pressures at 20°C and at 25°C were calculated from the regression equation:

 

Vapour pressure at 20°C:

1.35* 10-01Pa

Vapour pressure at 25°C:

2.08* 10-01Pa

 

The linear regression of log P vs. 1/T gave a correlation coefficient r of - 1.0000, showing good repeatability and precision. Therefore, the determination is considered as valid.

Conclusions:

For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
Vapour pressure at 20 °C: 1.35 * 10-01Pa
Vapour pressure at 25 °C: 2.08 * 10-01Pa
Executive summary:

The vapour pressure of the test item was determined at three different temperatures (30, 40 and 50 °C) following EU A.4 using the effusion method (weight loss). All experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 9 % and very good correlation.

Therefore, the result of the test can be considered valid.

For the test item the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C:          1.35* 10-01Pa

Vapour pressure at 25 °C:          2.08* 10-01Pa

Description of key information

The vapour pressure of the test item was determined at three different temperatures (30, 40 and 50 °C) following EU A.4 using the effusion method (weight loss). All experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 9 % and very good correlation.

Therefore, the result of the test can be considered valid.

For the test item the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C:          1.35* 10-01Pa

Vapour pressure at 25 °C:          2.08* 10-01Pa

Key value for chemical safety assessment

Vapour pressure:
0.135 Pa
at the temperature of:
20 °C

Additional information