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EC number: 813-338-6 | CAS number: 106155-02-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 30/4/1996 to 2/7/1996
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- (E)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol
- Cas Number:
- 106155-02-6
- Molecular formula:
- C13H22O
- IUPAC Name:
- (E)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol
- Reference substance name:
- (Z)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol
- Cas Number:
- 106155-03-7
- Molecular formula:
- C13H22O
- IUPAC Name:
- (Z)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol
- Reference substance name:
- Unknown impurities
- IUPAC Name:
- Unknown impurities
- Test material form:
- other: colorless fluid
Constituent 1
impurity 1
impurity 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Doses:
- Sighting study:
2000 mg/Kg bw and 5000 mg/Kg bw
Main study:
5000 mg/Kg bw (10 mL/Kg bw - No. of animals per sex per dose:
- Sighting study:
2 rats
Main study:
5 males and 5 females - Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 of the test item in rats was found to be >5000 mg/Kg bw
- Executive summary:
The acute oral toxicity in rats was determined according to the method recommended in OECD Guidelines 420 "Fixed dose method" from 1992.
The study was initiated with a sighting study. On the basis of the results of the sighting study, it was decided to carry out main study with dose of 5000 mg /Kg bw with a group of 10 animals.
Eight animals of the main study survived the treatment and showed moderate signs of toxicity
Under the experimental conditions described, the oral LD50 of the test item in rats was found to be >5000 mg/Kg bw
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