Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Daphnia:

Three studies are available to evaluate the acute toxicity to aquatic invertebrates

1) Key Study on a similar substance: Experimental study, guideline EPA OPPTS 850.1010, performed under GLP conditions.

The test item is the substance 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol (CAS 28219-61-6; EC 248-908-8).

Result is EC50(48h) = 1.4 mg/L

2) Supporting QSAR estimation on a similar substance: Estimation done with  ECOSAR v1.11 (QSAR model from the U.S. EPA)

The substance used for the calculation is 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol (CAS 28219-61-6; EC 248-908-8).

Result is EC50(48h) = 1.03 mg/L

3) Supporting QSAR estimation on the substance under registration (i.e as defined in section 1 of this dossier).

Estimation done with  ECOSAR v1.11 (QSAR model from the U.S. EPA)

Result is EC50(48h) = 1.7 mg/L

Fish:

The following LC-values were determined:

LC0 = 2.6 mg/L

LC50 = 6.3 mg/L

LC100 = 8.5 mg/L

Algae:

Three studies are available to evaluate the toxicity to aquatic algae:

1) Key Study on a similar substance: Experimental study, guideline EPA OPPTS 850.5400, performed under GLP conditions.

The test item is the substance 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol (CAS 28219-61-6; EC 248-908-8).

Result is EC50(96h) = 2.5 mg/L, NOEC(96h)=0.4 mg/L

2) Supporting QSAR estimation on a similar substance: Estimation done with  ECOSAR v1.11 (QSAR model from the U.S. EPA)

The substance used for the calculation is 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol (CAS 28219-61-6; EC 248-908-8).

Result is EC50(96h) = 1.9 mg/L

3) Supporting QSAR estimation on the substance under registration (i.e as defined in section 1 of this dossier).

Estimation done with  ECOSAR v1.11 (QSAR model from the U.S. EPA)

Result is EC50(96h) = 2.8 mg/L

Microorganismes:

The following effect concentrations were determined:

EC0: 30 mg/L

EC10: 100 mg/L

Additional information