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EC number: 308-783-3
CAS number: 98510-75-9
an acute dermal toxicity study according to EU Method B.3 and OECD
Guideline 402, 5 male and 5 female CD rats (Crl:COBS CD(SD)BR) were
dermally exposed to Coco AAPB (a.i
31 %) as delivered by the
sponsor for 24
hours to 10%
of total body surface at a dose
of 2000 mg/kg
bw (limit test). Test sites were
covered with an occlusive
24 hours, the test sites were rinsed with warm water. Animals then were
observed for 14 days after dosing.
There were no clinical signs of systemic
reaction to treatment. Sites of application of the test substance showed
slight or well-defined erythema in all animals on Day 2 and/or 3. On Day
4 and Day 5, slight erythema were seen in three male and four female
rats, sloughing in two male rats and one female rat and
hyperkeratinisation in three female rats. All skin reactions were
completely reversible by Day 6 in all animals. Slightly low bodyweight
gains were recorded for three females on Day 8. All other rats achieved
anticipated bodyweight gains throughout the study. Terminal autopsy
findings were normal.
Combined: 2000 mg/kg bw
Combined: > 2000 mg/kg bw
Coco AAPB (a.i.
31 %) is of low toxicity based on the LD50 in males and
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