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EC number: 308-783-3
CAS number: 98510-75-9
Irritant/corrosive response data for one animal at each observation time
up to removal of each animal from the test
Score at time point / Reversibility
- opacity -
Max. score 4
Max. score: 4
Max. score: 2
Max. score: 3
In addition extreme bleeding of conjunctivae
and nictating membrane, blood coloured discharge, reddened iris.
After the 1 h scoring the animals was
humanely killed because of the severity of effects.
a primary eye irritation study according to EU Method B.5 (1992) and
OECD Guideline 405 (1987), 100 mg of Coco AAPB (99.4
% dry solids) was instilled into the conjunctival sac of one New Zealand
white rabbit. The
eye was not rinsed after test substance instillation.
After the first scoring one hour after test substance instillation, the
test was terminated. Irritation was
scored according to Draize as stipulated in the guidelines.
The treated eye showed 1 h after dosing
extreme bleeding of conjunctivae and nictating membrane, blood coloured
discharge, reddened iris, cornea opacity score 2 of one half of the
cornea, iritis score 1, conjunctival erytheme and chemosis score 3. The
untreated control eye showed no abnormalities.
After this scoring the animals was humanely
killed because of severity of effects.
this study, Coco AAPB (99.4 % dry solids) caused irreversible effects on
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