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EC number: 308-783-3
CAS number: 98510-75-9
on oral, inhalative and dermal absorption, distribution and excretion is
not available for the target substance Undecylenamidopropyl Betaine.
considerations based on physicochemical properties a moderate to high
dermal absorption is anticipated if the water solubility is between
100-10,000 mg/L. A molecular weight of less than 100 favours dermal
uptake. Above 500 the molecule may be too large. For substances with log
Kow values <0, poor lipophilicity will limit penetration into the
stratum corneum and hence dermal absorption.
molecular weight (327.48 g/mol) and water solubility (3.1 g/L at 20°C)
of the target substance Undecylenamidopropyl Betaine are in a range
suggesting dermal absorption, the low log Kow of -1.38 as well as the
ionic nature suggest that the substance is not likely to be sufficiently
lipophilic to cross the stratum corneum, therefore dermal absorption is
likely to be low.
data on metabolism and distribution are available for the oral and
dermal route conducted with source substance C12
AAPB and for the dermal route conducted with the source substance Coco
fate of C12 AAPB in the rat was studied in an ADME study (ADME -
absorption, distribution, metabolism, excretion) comparable to OECD
differentially labelled samples were used:
(N(lauroylaminopropyl)-N,N-dimethyl-N-carboxymethyl ammonium (inner)
carboxylate) isotopically labelled with14C in the carboxymethyl ammonium
moiety ([14C]TB) and N(lauroylaminopropyl)-N,N dimethyl-N-carboxymethyl
ammonium (inner) carboxylate, isotopically labelled with14C in the 1
carbon of the lauroyl moiety ([1-14C]TB).
gavage administration, C12 AAPB is poorly absorbed from the intestinal
tract following administration in water at 30 mg/kg or 10 mg/kg bw,
respectively. Within 48 hours, approximately 5% of the 14C dose was
excreted in urine and < 2 % in expired air and < 2% remained in the
carcass. The remainder was excreted in the faeces as unchanged parent
body autoradiography confirmed that absorption from the gut was low and
that the tissues showing detectable levels of 14C were those
predominantly associated with urinary excretion (liver, kidney cortex,
urinary bladder). The urine contained traces of parent and an
unidentified polar metabolite. Although metabolism of absorbed material
is extensive, the lauryl moiety is not extensively removed from the rest
of the molecule judging by the relatively low amounts of 14CO2 produced.
application (approximately 20 mg/kg (approximately 0.3 mg/cm²)) of C12
AAPB 14C-labelled at the carboxymethyl ammonium or approximately 10
mg/kg (approximately 0.15 mg/cm²) of C12 AAPB 14C-labelled in the lauryl
moiety in water) followed by 48 h occlusion gave similar results. After
48 hours, approximately 3.5-6% (females) and 2-3.5% (males) was
absorbed. Urine was the major route of excretion for absorbed material
with expired air and faeces being relatively minor routes.
dermal permeation and penetration of Coco AAPB was investigated using
human skin in an in vitro study according to OECD guideline 428. Dermal
absorption was not detectable: the mean absorbed dose of the test item,
sum of the amounts found in the viable epidermis, dermis and receptor
medium was 0%.
similar low absorption via the oral, dermal and inhalative route is to
be expected for the target substance Undecylenamidopropyl
Betaine, based on close structural similarity to the source substances C12
AAPB and C8-18 and C18 unsatd. AAPB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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