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EC number: 308-783-3
CAS number: 98510-75-9
Preliminary study:Mortality:1000 mg/kg bw: 4/4 animals died within 30 hours after first administration 2000 mg/kg bw: 4/4 animals died within 4 hours after first administration
In a OF1
(I.O.P.S. Caw) mouse bone marrow micronucleus assay, performed as
described by W. Schmid - The Micronucleus test, Mutation Research, 31,
9-15 (1975), 5 male and 5 female animals were treated i. p. with Coco
AAPB (30 % a.i). The test method by W. Schmidt is
almost equivalent to the procedure described by OECD guideline 474. In
a preliminary study the test animals were administered twice (in a 24
hours interval) each 100, 200, 500, 1000 and 2000 mg/kg bw/day by
intraperitoneal injection. Clinical signs and mortality were observed up
to 30 hours after the first administration. Clinical signs like
piloerection and ptosis were seen at doses of >/= 100 mg/kg bw/day. At
doses >/= 1000 mg/kg bw/day the mice died within 30 and 4 hours after
the first administration. The tolerated doses were in the range of 100
to 500 mg/kg bw/day. Therefore, the dose of 200 mg/kg bw/day was
selected as the high dose and 20 mg/kg bw/day (10 % of the high dose) as
the low dose. As the test substance was applied twice with a 24 h
interval (although only one timepoint was chosen for sacrifice), the
result of the sacrifice 6h later may be regarded as a result of a 30h
and a 6h treatment. The dose level of 200 mg/kg bw/day (corresponding to
60 mg active substance/kg bw/day) is considered to be sufficiently high
based on the effects found in the preliminary study and due to the
highly irritating properties of the compound.
The mean number of micronucleated
erythrocytes/1000 polychromatic erythrocytes in males and female mice at
20 and 200 mg/kg bw/day were unaffected compared to the negative
controls. The administration of 100 mg cyclophosphamide/kg bw serving as
the positive control led to clearly elevated numbers of micronucleated
It can be concluded, that Coco AAPB (30
% a.i) induced no clastogenic effect in this in vivo cytogenicity
study on mice at dose levels of 20 and 200 mg/kg bw/day.
is classified as acceptable. This study satisfies the requirement for
Test Guideline OECD 474 for in vivo cytogenetic mutagenicity
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