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EC number: 237-529-3 | CAS number: 13826-66-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-04-29 to 2015-05-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 166 g/L
- Temp.:
- 10 °C
- pH:
- 0.52
- Remarks on result:
- other: without pH adjustment
- Key result
- Water solubility:
- 169 g/L
- Temp.:
- 20 °C
- pH:
- 0.48
- Remarks on result:
- other: without pH adjustment
- Water solubility:
- < 0.4 mg/L
- Temp.:
- 10 °C
- pH:
- 4.02
- Remarks on result:
- other: with pH adjustment to pH 4
- Water solubility:
- < 0.4 mg/L
- Temp.:
- 20 °C
- pH:
- 4.02
- Remarks on result:
- other: with pH adjustment to pH 4
- Water solubility:
- < 0.05 mg/L
- Temp.:
- 20 °C
- pH:
- 9
- Remarks on result:
- other: with pH adjustment to pH 7
- Water solubility:
- < 0.05 mg/L
- Temp.:
- 20 °C
- pH:
- 9
- Remarks on result:
- other: with pH adjustment to pH 9
- Details on results:
- Preliminary experiment 1:
ICP-AES measurement of dissolved Zr without pH adjustment of the test solution indicated that water solubility is > 100 g/L. Between pH 4 and 7, all Zr precipitated from the test solution, as no measurable dissolved Zr levels could be observed from pH 7 on.
Preliminary experiment 2:
ICP-MS measurement of dissolved Zr without pH adjustment of the test solution (nominal loading rate 10 g test item/L) yielded a water solubility of 7.98 g/L. The following results were obtained at different pH levels:
- pH 4: 1.13 g/L
- pH 7: < 0.05 g/L
- pH 9: < 0.05 g/L
However, these results of preliminary experiment 2 should be considered with caution because:
- ICP-MS showed too low recoveries (80%) due to physical interference caused by the special properties of the test item, therefore it was decided to change to ICP-AES in the main test. For ICP-AES, the recoveries were effectively much higher and confirmed the composition of the test item as indicated by the sponsor.
Main test:
In the main test using ICP-AES, the following conditions were also applied:
- Loading rate in the main test was much higher as in preliminary experiment 2 (as was already clear from the first preliminary experiment).
- It was decided not to include the pH 7 and 9 adjustments in the main test as the physical interference had no influence on the quantification limit and it was proven in the two preliminary experiments that at pH 7 and 9 all results were below the quantification limit.
Preliminary information (non-GLP) revealed that the water solubility was higher than 100 g/L test item. Attemps made with 300 and 500 g/L were not successful because the solutions could not be stirred anymore. With 200 g/L, it was possible to carry out the test however the test item was not fully soluble at this test concentration. Based on these results, the loading rate of 200 g/L was selected as optimal for the main study, because the maximal water solubility of the test item (without pH adjustment) appeared to be > 100 g/L but < 200 g/L.
At this loading rate of 200 g/L and without pH adjustment, 44.4 and 45.5 g Zr/L were measured at 10 and 20 °C, respectively; corresponding to 166 and 169 g test item/L at these two temperatures. The main study also investigated the water solubility at pH = 4 and revealed that no zirconium was detected at this pH.
N.B. Values retained for reporting in the IUCLID field just above and entitled “Water solubility” were thus the following:
- Without pH adjustment: values determined in the main test
- pH = 4: values determined in the main test
- pH = 7: values determined in preliminary experiment 2
- pH = 9: values determined in preliminary experiment 2 - Conclusions:
- The water solubility of the test item (hydrated form of zirconium dinitrate oxide) was determined to be 169 g/L at 20 °C. This maximal water solubility corresponds to a solubility of 115 g/L for anhydrous zirconium dinitrate oxide (substance as registered). Dissolution of the test substance was accompanied with a strong pH decrease of the test solution down to a pH of ca. 0.5. When adjusting pH to 4, 7 or 9, zirconium appears to disappear from the test solution due to precipitation.
Reference
Results : without pH adjustment (at 20°C):
Equilibration time |
Water solubility at 20 °C: Concentration in g Zr / L |
|||
1st |
2nd |
3rd |
Mean |
|
Day 1 |
44.9 |
46.3 |
45.5 |
45.6 |
Day 2 |
45.4 |
45.9 |
45.2 |
45.5 |
Day 3 |
45.2 |
45.9 |
44.8 |
45.3 |
Overall mean |
45.5 |
|||
Overall standard deviation |
0.1 |
Equilibration time |
Water solubility at 20 °C: Concentration in g test item / L |
|||
1st |
2nd |
3rd |
Mean |
|
Day 1 |
167 |
173 |
170 |
170 |
Day 2 |
169 |
171 |
168 |
170 |
Day 3 |
168 |
171 |
167 |
169 |
Overall mean |
169 |
|||
Overall standard deviation |
1 |
Results: adjustment to pH 4 (at 20°C):
Equilibration time |
Water solubility at 20 °C: Concentration in mg Zr / L |
|||
1st |
2nd |
3rd |
Mean |
|
Day 1 |
< 0.1 |
< 0.1 |
< 0.1 |
< 0.1 |
Day 2 |
< 0.1 |
< 0.1 |
< 0.1 |
< 0.1 |
Day 3 |
< 0.1 |
< 0.1 |
< 0.1 |
< 0.1 |
Overall mean |
< 0.1 |
|||
Overall standard deviation |
------ |
Equilibration time |
Water solubility at 20 °C: Concentration in mg test item / L |
|||
1st |
2nd |
3rd |
Mean |
|
Day 1 |
< 0.4 |
< 0.4 |
< 0.4 |
< 0.4 |
Day 2 |
< 0.4 |
< 0.4 |
< 0.4 |
< 0.4 |
Day 3 |
< 0.4 |
< 0.4 |
< 0.4 |
< 0.4 |
Overall mean |
< 0.4 |
|||
Overall standard deviation |
------ |
Results: adjustment to pH 7 (at 20°C):
Equilibrium time |
Water solubility at 20 °C: Concentration in mg Zr / L |
|||
1st |
2nd |
3rd |
Mean |
|
Day 1 |
< 0.012 |
< 0.012 |
< 0.012 |
< 0.012 |
Day 2 |
< 0.012 |
< 0.012 |
< 0.012 |
< 0.012 |
Day 3 |
< 0.012 |
< 0.012 |
< 0.012 |
< 0.012 |
Overall mean |
< 0.012 |
|||
Overall standard deviation |
------ |
Equilibrium time |
Water solubility at 20 °C: Concentration in mg test item/ L |
|||
1st |
2nd |
3rd |
Mean |
|
Day 1 |
< 0.05 |
< 0.05 |
< 0.05 |
< 0.05 |
Day 2 |
< 0.05 |
< 0.05 |
< 0.05 |
< 0.05 |
Day 3 |
< 0.05 |
< 0.05 |
< 0.05 |
< 0.05 |
Overall mean |
< 0.05 |
|||
Overall standard deviation |
--- |
Results: adjustment to pH 9 (at 20°C):
Equilibrium time |
Water solubility at 20 °C: Concentration in mg Zr / L |
|||
1st |
2nd |
3rd |
Mean |
|
Day 1 |
< 0.012 |
< 0.012 |
< 0.012 |
< 0.012 |
Day 2 |
< 0.012 |
< 0.012 |
< 0.012 |
< 0.012 |
Day 3 |
< 0.012 |
< 0.012 |
< 0.012 |
< 0.012 |
Overall mean |
< 0.012 |
|||
Overall standard deviation |
------ |
Equilibrium time |
Water solubility at 20 °C: Concentration in mg test item/ L |
|||
1st |
2nd |
3rd |
Mean |
|
Day 1 |
< 0.05 |
< 0.05 |
< 0.05 |
< 0.05 |
Day 2 |
< 0.05 |
< 0.05 |
< 0.05 |
< 0.05 |
Day 3 |
< 0.05 |
< 0.05 |
< 0.05 |
< 0.05 |
Overall mean |
< 0.05 |
|||
Overall standard deviation |
------ |
Description of key information
The water solubility of zirconium dinitrate oxide (anhydrous) was determined to be 115 g/L at 20°C (corresponding to 169 g test substance/L that is hydrated dinitrate oxide) and pH 0.48 (Bauer, 2015). Dissolution of the substance is accompanied with a strong pH decrease. When adjusting pH to environmentally relevant values (i.e. pH = 4, 7 or 9), no measurable dissolved Zr levels could be observed.
Key value for chemical safety assessment
- Water solubility:
- 115 g/L
- at the temperature of:
- 20 °C
Additional information
A GLP study performed according to OECD guideline 105 and EC Method A.6 (Bauer, 2015) determined the water solubility of the test item to be 169 g/L at 20°C (value calculated based on measurement of 45.5 mg Zr/L by ICP-AES). The nominal loading rate of the test item was 200 g/L. Dissolution of the test substance was clearly accompanied with a pH decrease, as the pH of the test solutions was 0.48. Through recalculation, a water solubility of 115 g/L is obtained for anhydrous zirconium dinitrate oxide.
When adjusting the pH to 4, no dissolved Zr was observed at measurable levels in any of the samples during the main test. No measurements were performed at pH 7 and 9 in the main test, however, during the preliminary tests at a loading rate of 100 g/L (ICP-AES) and 10 g/L (ICP-MS), no measurable dissolved Zr could be observed at these pH levels.
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