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EC number: 231-208-1
CAS number: 7446-70-0
No valid data are available for aluminium chloride regarding
carcinogenicity. However, three valid in vitro and one in vivo
mutagenicity test, in part conducted with aluminium compounds with
bioavailabilities comparable to that of anhydrous aluminium chloride
(see section 7.1 of the IUCLID), gave no indication of a mutagenic
potential. The available repeated dose studies give no indication that
the test substance is able to induce hyperplasia or pre-neoplastic
lesions.Therefore, it is concluded that the test substance does not
suggest a specific alert for carcinogenicity, and a carcinogenicity
study is not proposed.
The International Agency for
Research on Cancer (IARC) has evaluated the carcinogenic risk of
industrial exposures in aluminium production to humans (IARC Monograph
100F, 2012, corresponding section of the report is attached) and has
concluded that there is sufficient evidence in humans for the
carcinogenicity of occupational exposures during aluminium production,
giving rise to cancer of the lung and bladder. However, the aluminium
exposure was confounded by exposure to other agents, including
polycyclic aromatic hydrocarbons, aromatic amines, nitro-compounds and
asbestos, most of which are known carcinogens.
In a recent opinion regarding
the safety of aluminium
from dietary intake (The EFSA Journal, 2008, 754, 1 -34, corresponding
section of the report is attached), the
Panel of Food Additives, Flavourings, Processing Aids and Food Contact
Materials (AFC) of the European Food Safety Authority (EFSA) refers
to the IARC evaluation and concludes that (quote) "There
is no evidence of increased cancer risk in non-occupationally exposed
persons and IARC did not implicate aluminium itself as a human
carcinogen." The Panel also noted "the absence of epidemiological
evidence for carcinogenicity of aluminium compounds used
therapeutically, and the conclusion of IARC that aluminium itself is
unlikely to be a human carcinogen, despite the observation of an
association between inhalation exposure to aluminium dust and aluminium
compounds during production/processing and cancer in workers." Overall,
the Panel concluded that "aluminium is unlikely to be a human carcinogen
at exposures relevant to dietary intake."
Committee on Consumer Safety (SCCS) concurs with the conclusions drawn
by the EFSA Panel in a recent opinion on the
safety of aluminium in
cosmetic products (SCCS/1525/14, corresponding section of the report is
The ATSDR (Agency for Toxic
Substances and Disease Registry, U.S. Department of Health and Human
Services) comes to the conclusion that the available data give no
indication that aluminium is a potential carcinogen. In its evaluation
document "Toxicological Profile for Aluminum" (2008), the ATSDR states: "The
available data do not indicate that aluminum is a potential carcinogen.
It has not been shown to be carcinogenic in epidemiological studies in
humans, nor in animal studies using inhalation, oral, and other exposure
routes (Oneda et al. 1994; Ondreicka et al. 1966; Pigott et al. 1981;
Schroeder and Mitchener 1975a, 1975b). Although these studies have
limitations ranging from use of only one species to a single exposure
level and limited histological examinations, the evidence strongly
suggests that aluminum is not carcinogenic, indicating that additional
carcinogenicity testing is not warranted at this time."
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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