Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-208-1
CAS number: 7446-70-0
Aluminium chloride basic was administered by daily
oral gavage to male and female Wistar rats at dose
levels of 40, 200 or 1000 mg/kg bw/day, corresponding
to 3.6, 18 and 90 mg/kg bw/day of elemental aluminium.
Males were exposed for 28 days, i.e. 2 weeks prior to
mating, during mating, and up to termintation. Females
were exposed for 37 to 53 days, i.e. during 2 weeks
prior to mating, during mating, during post-coitum,
and during at least 3 days of lactation.
Histopathological assessment revealed a mild to
moderate subacute inflammation of the glandular
stomach mucosa and minimal to moderate superficial
mucosal eosinophilic spheroids in both sexes at 1000
mg/kg bw/day. In males, these findings supported the
macroscopic findings of the glandular mucosa/limiting
ridge at this dose level. The mucosal eosinophilic
spheroids are apparently intracellular degenerative
products of the superficial mucosa and possibly
associated with the inflammation below the base of the
mucosa. These findings are indicatie of local
irritating properties of the test substance.
The slightly lower body weight and food intake of
females at 1000 mg/kg bw/day recovered to control
levels as treatment progressed. No toxicological
significance was therefore ascribed to these changes.
Changes in clinical pathology parameters at 1000 mg/kg
bw/day were of slight nature and generally within the
range expected for rats of this age and strain. Also,
any morphological correlates were absent. Therefore,
these changes were considered not indicative of organ
dysfunction and to be of no toxicologcal significance.
There were no further changes for mortality, clinical
signs, functional observations and organ weights that
were considered to be an effect of treatment.
The following NOAELs were established:
- NOAEL (parental animals) for systemic toxicity: 1000
- NOAEL (parental animals) for local effects on the
stomach: 200 mg/kg bw/day
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again