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EC number: 231-208-1
CAS number: 7446-70-0
Summary and Statistical Analysis of Micronucleus Data
Linear trend: z = -0.043
NS Not significant
+ Administered as a single dose
SD Standard deviation
Aluminium hydroxide was tested for its ability to induce micronuclei in
the polychromatic erythrocytes (PCE) of the bone marrow of treated rats.
In a range-finding study, no signs of toxicity were observed at 2000
mg/kg bw. Therefore, the animals were orally treated (gavage) with 500,
1000 and 2000 mg/kg bw of the test substance in the main study. Only
male animals were treated in the main experiment as the range finder
gave no indication of sex-specific differences regarding the effect of
the test compound.
Rats treated with Aluminium hydroxide at all doses exhibited group mean
%PCE that were similar to the vehicle control group and which were
comparable with the laboratory’s observed historical control data, thus
confirming there was no evidence of test article related bone marrow
Rats treated with Aluminium hydroxide at all doses exhibited MN PCE
frequencies that were similar to the vehicle control group and which
were considered consistent with the laboratory's historical data. There
were no statistically significant increases in micronucleus frequency
for any of the groups receiving the test article, compared to the
concurrent vehicle control. It is concluded that Aluminium hydroxide did
not induce micronuclei in the polychromatic erythrocytes of the bone
marrow of male rats treated up to 2000 mg/kg/day (the maximum
recommended dose for this study).
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