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EC number: 231-208-1
CAS number: 7446-70-0
The potential of Aluminium chloride anhydrous screened (PRD 30046443) to
cause dermal corrosion was assessed by a single topical application of
500 mg of the test substance to the Corrositex® Biobarrier Membrane
The Corrositex® Biobarrier Membrane is the test system consisting of a
reconstituted collagen matrix. The assay is based on the time that is
required for the test substance to penetrate through the Corrositex®
Biobarrier Membrane and produce a change in the Chemical Detection
In addition to the test substance a positive and a negative control were
The Corrositex® assay showed the following results:
The qualification screen demonstrated that the test substance is able to
react with the CDS and produce a visible color change. Therefore the
membrane barrier test method was determined to be suitable for the
evaluation of the corrosive potential of the test substance. A timescale
category test was carried out to distinguish between weak and strong
acids or bases. The test substance was assigned to timescale category 1
(having a high acid/alkaline reserve). In the main test four Corrositex®
Biobarrier Membranes were treated with the undiluted test substance.
The mean breakthrough time of the test substance, determined in the
actual Corrositex® assay, was 16 minutes and 52 seconds ( breakthrough
times for the individual membranes were 11:08, 19:00, 17:19, and 20:00).
These results indicate a corrosive potential of the test substance.
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