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Toxicological information

Carcinogenicity

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Description of key information

Two lifetime inhalation studies in rats (2 years) and mice (18 months) showed no significant treatment-related adverse non-carcinogenic or carcinogenic effect at the highest concentration tested (10000 ppm; 26000 mg/m3). Vinylidene fluoride is not considered to have carcinogenic effects based on the experimental data available.

Key value for chemical safety assessment

Carcinogenicity: via inhalation route

Endpoint conclusion
Dose descriptor:
NOAEC
26 000 mg/m³

Additional information

Two lifetime inhalation studies in rats (2 years, TNO (1991)) and mice (18 months, Bio/dynamics Inc. (1991)) showed no significant treatment-related adverse non-carcinogenic or carcinogenic effects at the highest dose tested (10000 ppm; 26000 mg/m3).

Based on the experimental data available, VDF is not considered to have carcinogenic effects.

Justification for classification or non-classification

Based on the absence of neoplastic lesions in rats exposed to concentrations up to 10000 ppm (26000 mg/m3) for 2 years, classification of vinylidene fluoride for carcinogenicity is not warranted according to EU Directive 67/548/EEC andEU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.