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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, comparable to guideline; minor restrictions in design and/or reporting but otherwise adequate for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1982
Reference Type:
study report
Title:
Unnamed
Year:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
200,000 ppm
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
Animals were observed for 7 days after exposure.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LCLo
Effect level:
> 200 000 ppm
Exp. duration:
1 h
Remarks on result:
other: Animals were observed for 7 days after exposure, no effects were noted
Mortality:
No mortality was observed.
Clinical signs:
No respiratory and skeletal reflex changes were observed. The animals remained alert and responsive to environmental stimuli.
Body weight:
No loss in body weight was observed.
Gross pathology:
No gross pathological changes were observed.

Applicant's summary and conclusion