Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: All information on this study, including the reliability grade, is derived from OECD SIDS 3-hydroxy-2-naphthoic acid CAS: 92-70-6 dated 2004-11-23, as the complete study report is not at hand.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2004
Report date:
2004

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 201 (Alga, Growth Inhibition Test)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-hydroxy-2-naphthoic acid
EC Number:
202-180-8
EC Name:
3-hydroxy-2-naphthoic acid
Cas Number:
92-70-6
Molecular formula:
C11H8O3
IUPAC Name:
3-hydroxynaphthalene-2-carboxylic acid

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
72 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
65.3 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: 95% CL: 57.6-75.9 mg/L
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
26.1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
biomass
Remarks on result:
other: 95% CL:21.6-31.6 mg/L
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
6.8 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
6.8 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
biomass

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Remarks:
Increase of the cell concentration in the control cultures by a factor of at least 16 within three days was not verified (no data on cell number at test end)
Conclusions:
The 72h-EC50 values for the growth rate (r) and biomass (b) determined in this study were 65.3 and 26.1 mg/L, respectively. The NOEC was 6.8 mg/L for both parameters.
Executive summary:

In a 72-h toxicity study, green algae (Pseudokirchneriella subcapitata) were exposed to 3-hydroxy-2-naphthoic acid at nominal concentrations of 0 (control), 2.0, 3.7, 6.8, 13, 23, 43, and 80 mg/L in accordance with OECD Guideline 201 and in compliance with GLP. Reliability grade 1 was assigned. The 72-hour EC50 for the growth rate was 65 mg/L. The 72-hour EC50 for the biomass was 26 mg/L. The NOEC for both parameters was 6.8 mg/L.