3-hydroxy-2-naphthoic acid

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

October 21-30, 1992

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study (OECD), GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Report date:

1993

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Version / remarks:

[adopted 1984]

Deviations:

not specified

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method C.2 (Acute Toxicity for Daphnia)

Version / remarks:

EEC Directive 79/831, Annex V Methods for the Determination of Ecotoxicology, 5.1.2 Acute Toxicity for Daphnia , 1990

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3-hydroxy-2-naphthoic acid

EC Number:

202-180-8

EC Name:

3-hydroxy-2-naphthoic acid

Cas Number:

92-70-6

Molecular formula:

C11H8O3

IUPAC Name:

3-hydroxynaphthalene-2-carboxylic acid

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

106 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 2

Duration:

48 h

Dose descriptor:

EC0

Effect conc.:

56 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 3

Duration:

48 h

Dose descriptor:

EC100

Effect conc.:

180 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Remarks:

In the control, not more that 10% of the daphnids have been immobilised.; the dissolved oxygen concentration at the end of the test was > 3 mg/L in control and test vessels (OECD 202, adopted 2004) respectively ≥60% of the air saturation value at the temp

Conclusions:

The 48h-EC50 determined in this study was 106 mg/L

Executive summary:

In a 48-h toxicity study, daphnids (Daphnia magna) were exposed to 3-hydroxy-2-naphthoic acid at nominal concentrations of 0 (control), 10, 18, 32, 56, 100, and 180 mg/L under static conditions in accordance with OECD Guideline 202 and EU Method C.2 and in compliance with GLP. Reliability grade 1 was assigned. Immobilization was observed daily. The 48-hour EC50 was 106 mg/L. The 48-EC0 based on immobilization was 56 mg/L.