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EC number: 213-234-5
CAS number: 931-36-2
- Viability / Mortality: No deaths occurred
during the study period.
- Body Weights: The body weight of the
animals, recorded prior to the first application and prior to treatment
with 3HTdR, was within the range commonly recorded for animals of this
strain and age.
- Lymph Node Weights and Cell Counts: The
measured lymph node weights and –cell counts of all animals treated were
recorded after sacrifice. A statistically significant and biologically
relevant increase in lymph node weight and –cell count was obtained in
the high dose group in comparison to the vehicle control group
(p<0.001). For BALB/c mice, a cutoff-value for the lymph node cell count
index of 1.55 was reported for a positive response. The index determined
for the high dose group exceeded this threshold (index of 2.79).
- Ear Weights: The measured ear weights of
all animals treated were recorded after sacrifice. A statistically
significant increase in ear weights was observed in the high dose group
in comparison to the vehicle control group (p=0.006). For BALB/c mice, a
cutoff-value of 1.1 for the ear weight index was reported for a positive
response regarding ear skin irritation. None of the indices determined
for the test item treated groups exceeded this threshold. Furthermore,
the threshold value of 25% increase in ear weights for excessive local
skin irritation mentioned in OECD guideline 429 was not exceeded in any
Lymph Node Weights
Test item concentration (%)
Lymph node weight (mg)
Index = mean lymph node weight of test
item group related to vehicle group
* statistically significant increase
vs. control group (p < 0.001)
Lymph Node Cell Counts
Lymph node cell count (x10E6)
Index = mean lymph node cell count of
test item group related to vehicle group
Ear weight (mg)
Index = mean ear weight of test item
group related to vehicle group
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