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EC number: 213-234-5 | CAS number: 931-36-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- BASF-Test: Animals were treated for 4 hour using occlusive conditions. An application site of 2x2 cm was covered with the test substance. After the application time (4 h) the skin was washed with Lutrol (50%). The animals were observed for 8 days and skin changes were recorded daily. The report describes findings after 24 and 48 hours and at the end of the observation period (8 days).
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethyl-4-methylimidazole
- EC Number:
- 213-234-5
- EC Name:
- 2-ethyl-4-methylimidazole
- Cas Number:
- 931-36-2
- Molecular formula:
- C6H10N2
- IUPAC Name:
- 2-ethyl-4-methyl-1H-imidazole
- Details on test material:
- - Name of test material (as cited in study report): 2-Äthyl-4(5)-methylimidazol; EMI 2,4
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M.GAUKLER (6050 Offenbach)
- Weight at study initiation: male ca. 2.80 kg, female ca. 2.65 kg
- Diet: Sniff K, standard diet for rabbits and guinea pigs (Firma INTERMAST GMBH, Soest), ad libitum
- Water: ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 80 % aquatic solution (0.5 g)
- Duration of treatment / exposure:
- 4 hours and 1 hour
- Observation period:
- 8 days
- Number of animals:
- 2 per exposure duration
- Details on study design:
- TEST SITE
- Area of exposure: 2 x 2 cm
- Type of wrap: rubberised linnencloth, fixed with adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing: with Lutrol (50% or 100%) and dried with cellulose towels
- Time after start of exposure: 4 h and 1 h
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Time point:
- other: 4, 24, 48 hour
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: necrosis (soft movable, patchy)
- Irritation parameter:
- erythema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Time point:
- other: 8 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: necrosis (parchment-like)
- Irritation parameter:
- edema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Remarks:
- 1 h exposure
- Basis:
- mean
- Time point:
- other: 4, 24, 48 h and 8 d
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- 1 h exposure
- Basis:
- mean
- Time point:
- other: 4, 24, 48 h and 8 d
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Moderate to severe erythema and edema was observed after an exposure of 4 hours. No signs of erythema nor edema were observed after an exposure of 1 hour.
- Other effects:
- Clinical symptoms were not observed
Applicant's summary and conclusion
- Interpretation of results:
- other: irritating
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