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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethyl-4-methylimidazole
EC Number:
213-234-5
EC Name:
2-ethyl-4-methylimidazole
Cas Number:
931-36-2
Molecular formula:
C6H10N2
IUPAC Name:
2-ethyl-4-methyl-1H-imidazole
Details on test material:
- Name of test material (as cited in study report): 2-ethyl-4-methylimidazol
- Physical state: solid

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
100, 147, 215, 316 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 200 mg/kg bw
Based on:
test mat.
Mortality:
0/10 animals died at 100 mg/kg bw
0/10 animals died at 147 mg/kg bw
6/10 animals died at 215 mg/kg bw
10/10 animals died at 316 mg/kg bw
deaths occured within 1 hour
Clinical signs:
Dyspnea, apathy, belly-side position, staggering, atony, tremors, twitching, spastic gait, tonic-clonic convulsions, exophthalmos, poor general condition
Gross pathology:
No precipitation or adhesions.

Applicant's summary and conclusion