2-ethyl-4-methylimidazole

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Principles of method if other than guideline:

according to BASF-internal standard

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethyl-4-methylimidazole

EC Number:

213-234-5

EC Name:

2-ethyl-4-methylimidazole

Cas Number:

931-36-2

Molecular formula:

C6H10N2

IUPAC Name:

2-ethyl-4-methyl-1H-imidazole

Details on test material:

- Name of test material (as cited in study report): 2-ethyl-4-methylimidazol
- Physical state: solid

Test animals

Species:

mouse

Strain:

NMRI

Sex:

male/female

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

water

Doses:

100, 147, 215, 316 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 200 mg/kg bw

Based on:

test mat.

Mortality:

0/10 animals died at 100 mg/kg bw
0/10 animals died at 147 mg/kg bw
6/10 animals died at 215 mg/kg bw
10/10 animals died at 316 mg/kg bw
deaths occured within 1 hour

Clinical signs:

Dyspnea, apathy, belly-side position, staggering, atony, tremors, twitching, spastic gait, tonic-clonic convulsions, exophthalmos, poor general condition

Gross pathology:

No precipitation or adhesions.