Registration Dossier
Registration Dossier
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EC number: 700-891-2 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
C12-C22 Alkyl polyglycosides are UVCB consisting of a mixture of fatty acid and glycosides. This category consists of 7 members judged as similar based on the weight of evidence (i.e. physicochemical properties, tolerance, and systemic safety). The available data (mainly the sub-acute data) show that C12-C22 alkyl polyglycosides will probably be absorbed to a low extent via the skin and via inhalation and via the gastro-intestinal-tract. Actually, 4 independent studies result all at the same NOAEL (i.e. 1000 mg/kg/day, the highest dose tested). Thus, in a weight of evidence dermal and oral absorption rates of C12-C22 Alkyl polyglycosides are assumed to be similar for all the members of this category since there aren’t any significant isolated adverse effects considered treatment-dependant. Due to their low water solubility and their resemblance C12-C22 Alkyl polyglycosidesand the metabolites (and their metabolites i.e. fatty acid, glycoside,) can have the same bioavailability in tissue of the organism. Moreover, considering the categorization-thinking on the fatty acid (C12-C22 fatty acid), one can extend this approach to C12-C22 Alkyl polyglycosides category. Therefore, the toxicokinetic investigation is judgednon relevant for any member from this category.
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