Registration Dossier
Registration Dossier
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EC number: 604-351-6 | CAS number: 143390-89-0
Biodegradation in soil
Administrative data
- Endpoint:
- biodegradation in soil
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study with analytical monitoring
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
- Reference Type:
- other: FOCUS calculation
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: BBA-Guideline for the official testing of plant protection products, part IV, 4-1.
- GLP compliance:
- yes
- Test type:
- laboratory
Test material
- Reference substance name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- EC Number:
- 604-351-6
- Cas Number:
- 143390-89-0
- Molecular formula:
- C18 H19 N O4
- IUPAC Name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- Details on test material:
- - Name of test material (as cited in study report): reg. No. 242 009, BAS 490 F
- Analytical purity: > 99%
- Lot No.: 311/2
- Radiochemical purity: 100%
- Specific activity (if radiolabelling):4.410 KBq/µg
- Locations of the label (if radiolabelling): (E)-2-[2-(2-Methylphenoxy)[phenyl-U- 14C]-methyl]-phenyl-2-(methoxyimido)acetic acid methyl ester
Constituent 1
- Radiolabelling:
- yes
Study design
- Oxygen conditions:
- aerobic
- Soil classification:
- DIN 19863 (Deutsche Industrie-Norm)
Soil properties
- Soil no.:
- #1
- Soil type:
- sandy loam
- % Clay:
- 13
- % Silt:
- 31
- % Sand:
- 56
- % Org. C:
- 1.7
- pH:
- 7.2
- CEC:
- 14.7 other: mVal/100g
- Details on soil characteristics:
- SOIL COLLECTION AND STORAGE
- Geographic location: Limburger Hof Bruch West, Germany
- Sampling depth (cm): 0-20 cm
Duration of test (contact time)
- Soil No.:
- #1
- Duration:
- 183 d
Initial test substance concentration
- Soil No.:
- #1
- Initial conc.:
- 0.5 mg/kg soil d.w.
- Based on:
- act. ingr.
- Parameter followed for biodegradation estimation:
- radiochem. meas.
- test mat. analysis
Experimental conditions
- Soil No.:
- #1
- Temp.:
- 20 ± 2 °C
- Humidity:
- 40% of the maximum water holding capacity
- Details on experimental conditions:
- EXPERIMENTAL DESIGN
- Pretreatment of the soil: The soil was treated nominally with 0.5 mg/kg 14C-Reg. No. 242 009 dissolved in MeOH. The soil was homogenized and brought to a moisture of 40% of the maximum water holding capacity and incubated in the dark at 20 ± 2 °C.
- Test vessel: glass dishes
- Fill volume: 100 g soil d.w.
- Sampling intervals: after 0, 1, 2, 14, 28, 90, 181, 272, 363 days
- Aeration: Incubator was purged with moistened air
- Details of traps for volatiles: three adsorption traps filled with ethylenglycol, 0.5 M NaOH
Results and discussion
Material (mass) balanceopen allclose all
- Soil No.:
- #1
- % Recovery:
- 98.7
- Remarks on result:
- other: after 0 days
- Soil No.:
- #1
- % Recovery:
- 103.8
- Remarks on result:
- other: after 28 days
- Soil No.:
- #1
- % Recovery:
- 81.1
- Remarks on result:
- other: after 183 days
Half-life / dissipation time of parent compoundopen allclose all
- Soil No.:
- #1
- DT50:
- 0.56 d
- Type:
- other: single first order
- Remarks on result:
- other: DT90 =1.85 days; half-life values estimated by FOCUS modelling
- Soil No.:
- #1
- DT50:
- < 3 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: DT90 < 3 days; half-life values based on measurements
- Transformation products:
- yes
Identity of transformation products
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- BF 490-1
- Identifier:
- common name
- Identity:
- BF 490-1
- Details on transformation products:
- DT50 = 38 days
DT90 = 127 days
- Description of biotransformation pathway: BAS 490 F is demethylated to the corresponding acid BF 490-1. No further intermediate was detected because the simple aromatic structure of SF 490-1 allowed rapid degradation. CO2 and "bound residues" were found to be the dominating products of biodegradation. - Residues:
- yes
- Details on results:
- - Amount of residual radioactive residues: maximum of 0.212 mg/kg reach at Day 90 until Day 183
- Humic substances: most radioactivity was found in humins, only minor amounts could be dissolved
- Mineralisation rate: after 90 days about 1/5 of IRR was mineralized, after 146 days about 1/4 was mineralized
Applicant's summary and conclusion
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