Registration Dossier
Registration Dossier
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EC number: 203-950-6 | CAS number: 112-24-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study did not follow any guideline and was not performed according to GLP. Route is i.p. Limited reporting.
Data source
Reference
- Reference Type:
- publication
- Title:
- Neuropharmacological actions of some binuclear lanthanide(III) complexes
- Author:
- Williams, L.A.D., Howell, R.C. Young, R., Kahwa, I.A.
- Year:
- 2 001
- Bibliographic source:
- Comparative Biochemistry and Physiology Part C 128 119-125
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
Test material
- Details on test material:
- TETA was obtained from Shell Chemical Co. (no further details provided)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 10% DMSO in physiological saline
- Doses:
- 20, 40, 60 and 80 mg/kg bw
- No. of animals per sex per dose:
- 10 per group (sex unknown)
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 38.5 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 31.4 - 45.7
Applicant's summary and conclusion
- Conclusions:
- The 24-h LD50 via ip injection in mice was 38.5 mg/kg bw
- Executive summary:
In an experimental study in mice, also the 24 -h LD50 value of TETA following intraperitoneal injection was evaluated. This value turned out to be 38.5 mg/kg bw with (95%) confidence limits of 31.4 and 45.7 mg/kg bw.
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