Registration Dossier
Registration Dossier
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EC number: 203-950-6 | CAS number: 112-24-3
Endpoint summary
Administrative data
Description of key information
Based on the results from the Acute Exposure Oral Toxicity in rats, the acute oral LD50 for males, females and combined sexes was determined to be 1861.9 (1383.5 - 2505.7) mg/kg, 1591.4 (1283.5 - 1973.3) mg/kg and 1716.2 (1446.5 - 2036.1) mg/kg, respectively.
No valid data available for acute inhalation toxicity that can be used for classification and labelling; the studies performed were intended to examine the toxicity of the vapour under realistic exposure conditions.
Based on the observations made in the Acute Exposure Dermal Toxicity Study in rabbits, the acute dermal LD50 in males and combined sexes for 6933-6-20 was determined to be 1720.0 (1082.9-2732.0) mg/kg and 1465.4 (1074.6-1998.3) mg/kg, respectively. The data generated for the acute dermal LD50 in females did not lend itself to the statistical method employed.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 716 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 465 mg/kg bw
Additional information
Three old inhalation studies were available in which rats had been exposed to the vapour of TETA generated at room T (21 or 25 degrees C) or at 100 degrees C for a single period of 7 to 8 hours. No mortality occurred. In none of the studies the concentration had been measured. It was, however, noted that in one of the studies no substance loss but an increase in substance weight was recorded. This is an indication that the test substance is hygroscopic and only a marginal fraction of the test substance might have been volatile. From a toxicologists point of view it is therefore doubtful if the animals were exposed to the test substance by inhalation and which concentration the generated vapour was of.
Justification for classification or non-classification
Based on the acute oral and dermal study classification is needed in GHS Category 4. The acute inhalation studies performed could not be used for classification.
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