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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer reviewed data base

Data source

Reference
Reference Type:
review article or handbook
Title:
not titel
Author:
Bajaj, H. C.; Kumar, K.; Nigam, P. C.;
Year:
1981
Bibliographic source:
Bajaj, H. C.; Kumar, K.; Nigam, P. C.; IJCADU;
Indian J. Chem. Sect. A; EN; 20; 11; 1981; 1070-1074, cited in Beilstein 29.01.2007

Materials and methods

Test guideline
Guideline:
other: measured
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trientine
EC Number:
203-950-6
EC Name:
Trientine
Cas Number:
112-24-3
Molecular formula:
C6H18N4
IUPAC Name:
N,N'-bis(2-aminoethyl)ethane-1,2-diamine

Results and discussion

Dissociating properties:
yes
Dissociation constantopen allclose all
No.:
#1
pKa:
3.25
Temp.:
25 °C
Remarks on result:
other: potentiometric, H2O, a1/apparent
No.:
#2
pKa:
6.55
Temp.:
25 °C
Remarks on result:
other: potentiometric, H2O, a2/apparent
No.:
#3
pKa:
9.08
Temp.:
25 °C
Remarks on result:
other: potentiometric, H2O, a3/apparent
No.:
#4
pKa:
9.8
Temp.:
25 °C
Remarks on result:
other: potentiometric, H2O, a4/apparent

Applicant's summary and conclusion