Registration Dossier
Registration Dossier
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EC number: 213-367-9 | CAS number: 939-97-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study was conducted according to an internal BASF method.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-tert-butylbenzaldehyde
- EC Number:
- 213-367-9
- EC Name:
- 4-tert-butylbenzaldehyde
- Cas Number:
- 939-97-9
- Molecular formula:
- C11H14O
- IUPAC Name:
- 4-tert-butylbenzaldehyde
- Details on test material:
- - Name of test material (as cited in study report): p-Tertbutyl-benzaldehyde
- Analytical purity: 98 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aqueous CMC preparation with one or two drops Cremophor EL
- Details on exposure:
- Concentration of the test material in vehicle:
- 2 %
-Amount of test material applied per gavage:
- 10 ml/kg bw - Doses:
- 200 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: prior to application of the test material and on days 3, 7 and 13.
- Necropsy of survivors performed: yes. Deceased animals and those sacrificed at the end of the observation period (on day 14 after dosing) were necropsied.
Results and discussion
- Mortality:
- males: 2/5 animals died after 1 and 2 hours
females: 2/5 animals died after 1 and 4 hours - Clinical signs:
- Symptoms:
Dyspnea, apathy, staggering, spastic movement , ruffled fur, bad general condition - Body weight:
- Body weight males/females (g)
before start: 22/22
after 2-4 d: 22/23
after 7 d: 26/24
after 9-13 d: 29/26 - Gross pathology:
- Dead animals:
no substance-related depositions or agglutinations.
Sacrificed animals:
1 animal with intraabdominal agglutinations
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
