4-tert-butylbenzaldehyde

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The study was conducted according to an internal BASF method. The test was performed according to Smith (Am . Ind . Hyg . Ass . J . 23, 95 - 107; 1962; In principle as described in OECD Guideline 403, from 12 May 1981). Analytical determination of the atmosphere was not performed (only recalculation via substance weight loss and cumulative air flow).

GLP compliance:

no

Test type:

other: inhalation hazard test (IHT)

Test material

Test material information

Constituent 1

Reference substance name:

4-tert-butylbenzaldehyde

EC Number:

213-367-9

EC Name:

4-tert-butylbenzaldehyde

Cas Number:

939-97-9

Molecular formula:

C11H14O

IUPAC Name:

4-tert-butylbenzaldehyde

Details on test material:

- Name of test material (as cited in study report): p-Tertiaerbutyl-benzaldehyd
- Analytical purity: 98 %

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Average weight at study initiation: test 1: males 232 g, females 215 g; test 2: males 258 g, females 217 g

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- A saturated atmosphere was generated by bubbling 200 l/h air at 20 ° C through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 hours.

TEST ATMOSPHERE
- No analytical determination of the atmosphere concentration was performed. The nominal concentration was calculated as the quotient of the amount of test substance weight loss during the exposure and the amount of air used during the exposure.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

saturated vapour-air mixture (0.142 mg/l => 21.14 ppm), calculated by the substance weight loss and cumulative air flow during study.

No. of animals per sex per dose:

3 males and 3 females per experiment; 2 experiments with test material and 1 air-control

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Endpoints examined: mortality and clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.142 mg/L air

Remarks on result:

other: Nominal concentration, not analytically verified

Mortality:

0/12

Clinical signs:

other: Nothing abnormal detected.

Body weight:

The body weight was determined prior to the beginning of the experiment only.

Gross pathology:

Nothing abnormal detected.