Registration Dossier
Registration Dossier
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EC number: 213-367-9 | CAS number: 939-97-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
After 5-day oral administration of p-tert-butylbenzaldehyde (TBB) to rats at doses of 12.5 and 50 mg/kg bw/day, p-tert-butylbenzoic acid (TBBA) was identified as metabolite in the urine 24 hours after the last administration, but not the secondary metabolite p-tert-butylhippuric acid (TBHA) was found. Further metabolites have not been investigated. Since TBBA is only slightly water soluble, this metabolite is probably present in the urine in the form of glucuronic acid conjugate, which could not be identified by the analytic method used. Furthermore, oxidation of the p-tert-butyl group may lead to p-tert-hydroxybutylbenzoic acid and p-tert-carboxybenzoic acid as additional metabolites (Giv B-96'128).
On the occasion of various 5 day oral toxicity studies of TBB, mice, guinea pigs and dogs were administered 100 mg/kg bw/d TBB for 5 days, and urine was collected for 24 h after the last administration and analyzed for the different metabolites, i.e. TBBA and TBHA by GC analysis. TBBA was determined as metabolite in urine samples of treated dogs, guinea pigs and at very low levels in the urine of mice. However, TBHA was found to be at higher levels in urine samples of treated mice and guinea pigs compared to TBBA, whereas TBHA levels tended to be lower in the urine of dogs than TBBA levels (Giv BS-96'137).
Similar 5 day oral-toxicity menagerie studies in rats, mice, guinea pigs, dogs and monkeys have been performed with substances, which were considered to follow similar metabolic pathways, i.e. lysmeral (CAS 80 -54 -6) and t-butyltoluene (TBT, CAS 98 -51 -1). In line, considering the relation between TBBA and TBHA, the main urinary metabolite in orally treated rats, dogs and rhesus monkeys was found to be TBBA, whereas in the guinea pig and mouse TBHA predominates.
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