Registration Dossier
Registration Dossier
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EC number: 232-189-2 | CAS number: 7789-78-8
Endpoint summary
Administrative data
Description of key information
Skin and eye irritation of calcium hydride have been waived. CaH2 reacts violently or is ignited by air; reacts exothermically with water or moisture producing hydrogen and calcium hydroxide, releases flammable gases on contact with water. Due to these physico-chemical properties, CaH2 was not tested for skin and eye irritation.
Nevertheless CaH2, once reacted with either moisture or water, produces gas (hydrogen) and calcium hydroxide. Therefore, read-across with calcium hydroxide was reported for skin and eye irritation. In vivo data revealed that Ca(OH)2 is irritating to skin and eye which also support classification of CaH2 as skin/eye irritating Cat 2.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Conclusions:
- In the joint chemical report of calcium dihydroxide, three tests studying skin irritation on rabbit exist. Two key studies using the OECD guideline N°404 and one supporting study using OECD 402. In conclusion, the results of available in vivo skin irritation studies (rabbit) indicate that Ca(OH)2 is irritating to skin.
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Conclusions:
- In the joint chemical report of calcium dihydroxide, three tests studying eye irritation on rabbit and two ran on in vitro (HET-CAM) exist. Two key studies using the OECD guideline N°405 and three supporting study using OECD 405 and the in vitro HET-CAM. In conclusion, the available eye irritation studies (in vivo, rabbit), Ca(OH)2 caused irreversible lesions in the eye.
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
