Registration Dossier

Administrative data

Description of key information

Skin and eye irritation of calcium hydride have been waived. CaH2 reacts violently or is ignited by air; reacts exothermically with water or moisture producing hydrogen and calcium hydroxide, releases flammable gases on contact with water. Due to these physico-chemical properties, CaH2 was not tested for skin and eye irritation.

Nevertheless CaH2, once reacted with either moisture or water, produces gas (hydrogen) and calcium hydroxide. Therefore, read-across with calcium hydroxide was reported for skin and eye irritation. In vivo data revealed that Ca(OH)2 is irritating to skin and eye which also support classification of CaH2 as skin/eye irritating Cat 2.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Referenceopen allclose all

Endpoint:
skin irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reference:
Composition 0
Test material information:
Composition 1
Conclusions:
In the joint chemical report of calcium dihydroxide, three tests studying skin irritation on rabbit exist. Two key studies using the OECD guideline N°404 and one supporting study using OECD 402. In conclusion, the results of available in vivo skin irritation studies (rabbit) indicate that Ca(OH)2 is irritating to skin.
Endpoint:
skin corrosion: in vitro / ex vivo
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Link to relevant study records

Referenceopen allclose all

Endpoint:
eye irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reference:
Composition 0
Test material information:
Composition 1
Conclusions:
In the joint chemical report of calcium dihydroxide, three tests studying eye irritation on rabbit and two ran on in vitro (HET-CAM) exist. Two key studies using the OECD guideline N°405 and three supporting study using OECD 405 and the in vitro HET-CAM. In conclusion, the available eye irritation studies (in vivo, rabbit), Ca(OH)2 caused irreversible lesions in the eye.
Endpoint:
eye irritation: in vitro / ex vivo
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Justification for classification or non-classification