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Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

Three reliable (Klimish score 1) biodegradation screening studies were carried on the test substance, all according largely to OECD test guidelines and GLP. Two of the studies were assessing ready biodegradation, based on OECD 301B methods (Zhao (2008) and Clarke (2007)) and the other assessed the inherent biodegradability based on the OECD 302C method. The maximum biodegradation measured in the ready biodegradation studies was 17.7% after 28 days. The biodegradation of the test substance was 1.4% after 28 days in the inherent biodegradation study.

The results of all three studies are consistent and demonstrate the test substance, Dantocol DHE is not readily biodegradable in water, nor does it demonstrate inherent biodegradation properties in water.

Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed

Additional information

Three reliable (Klimisch score 1) biodegradation screening studies were carried on the test substance, all according largely to OECD test guidelines and GLP. Two of the studies were assessing ready biodegradation, based on OECD 301B methods (Zhao (2008) and Clarke (2007)) and the other assessed the inherent biodegradability based on the OECD 302C method. The maximum biodegradation measured in the ready biodegradation studies was 17.7% after 28 days. The biodegradation of the test substance was 1.4% after 28 days in the inherent biodegradation study.

The results of all three studies are consistent and demonstrate the test substance, Dantocol DHE is not readily biodegradable in water, nor does it demonstrate inherent biodegradation properties in water.