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EC number: 248-052-5
CAS number: 26850-24-8
Based on the results of three OECD guideline screening studies for
biodegradation Dantocol DHE cannot be classified as readily or
inherently biodegradable (Clarke, 2007; Zhao, 2008; and Xue, 2015). The
adsorption coefficient (Koc) of Dantocol DHE is <17.8 with a Log Koc
<1.25 (Fox and Mullee, 2007). In addition, the Log Kow of Dantocol DHE
was measured as -1.32. The need for bioaccumulation testing is waived on
the basis of the Log Kow and a very low potential to accumulate.
Three reliable OECD guideline screening studies for biodegradation
are available for Dantocol DHE and are included in the dossier. The test
substance showed a maximum degradation of 17.7%, achieved after 28 days
in one of the Ready Biodegradation OECD 301B tests (Zhao 2008),
therefore not meeting the criteria for ready biodegradability and
indicating a potential persistence in the environment. An inherent
biodegradability test (OECD 302C) was also carried out, which provides
optimal conditions for degradation. In this study, the test substance
demonstrated a maximum of 1.4% degradation after 28 days. Based on these
results Dantocol DHE cannot be classified as inherently biodegradable
under the conditions of the test. In accordance with ECHA Guidance R.11
Figure R.11 -3, where the result of a MITI II (OECD 302C) Inherent
Biodegradability test demonstrates the test substance does not fulfill
the inherent biodegradability criteria, this indicates the test
substance will not degrade and must be classified as Persistent.
The adsorption coefficient (Koc) of Dantocol DHE has been
determined in according to the HPLC Screening OECD 121 guideline method.
This method uses the retention times of reference standards to generate
a calibration curve for determination of the adsorption characteristics
of the test substance. The retention time of the test substance was less
than all of the reference standards, with resulting calculated Koc and
Log Koc of <17.8 and <1.25 respectively. These values indicate that
Dantocol DHE will be unlikely to adsorb to soil and sludge and is likely
to have a very high mobility in the environment.
ECHA guidance states that where the Log Kow of the test substance
is ≤3, the requirement for bioaccumulation testing can be waived as the
test substance has a low potential to bioaccumulate. The Log Kow of
Dantocol DHE was measured as -1.32 and therefore the potential for
bioaccumulation is considered very low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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