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EC number: 248-052-5
CAS number: 26850-24-8
Three reliable short-term toxicity studies in fish (Klimisch 1) are
available for the test substance, Dantocol DHE. All three studies
followed internationally accepted study guidelines and were conducted
according to GLP.
Two of the studies assessed the short-term toxicity to fish of the test
substance, Dantocol DHE. Both the study with rainbow trout
(Onchorhynchus mykiss) and the study with zebra fish (Danio rerio) were
run at the single nominal test concentration of 100 mg/L and provided
96-hour LC50 values of >100 mg/L based on nominal test concentrations of
Dantocol DHE (Goodband and Mullee (2007) and Zhao (2007), respectively).
A prolonged toxicity study in zebra fish (Danio rerio) of Dantocol DHE
was conducted on a semi-static basis, over 14 days. The study was run at
the single nominal test concentration of 100 mg/L with test substance
renewal every 48 hours. The 14-day NOEC (mortality) was 100 mg/L based
on nominal test concentrations. Visual observations were made over the
14 day period for any toxic signs, none were observed. The weight and
length of the fish were measured at day 0 and at study termination. No
interpretation of weight and length data is provided in the report,
however visual inspection of the results indicates no difference between
the control and exposed groups over the 14 time period.
The results of all three studies are consistent and demonstrate that the
test substance, Dantocol DHE, does not cause significant toxicity to
freshwater fish, under the conditions of the test.
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