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EC number: 241-881-3 | CAS number: 17955-88-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
In the combined 28-day repeated dose toxicity study with the
reproduction/ developmental toxicity screening test, the reported NOAEL
for reproductive toxicity was greater than 1000 mg/kg bw. No
treatment-related changes were observed in any of the test animals.
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In the combined 28-day repeated dose toxicity study with the reproduction/ developmental toxicity screening test, 1,1,1,3,5,5,5-heptamethyl-3-octyltrisiloxane was tested according to OECD TG 422 and in compliance with GLP (Charles River, 2016).
The test item,1,1,1,3,5,5,5-heptamethyl-3-octyltrisiloxane, was formulated in dried and deacidified corn oil and administered orally (gavage) to 10 male and 10 female rats per group. An extra 5 animals per sex in the control and high dose group were included and allowed 14 days of recovery. All the animals were treated daily, for at least 28 days. Main males and recovery males were exposed to the test substance for 29 days. Main females were treated for 41 to 47 days. Recovery females were exposed for 43 days. The selected doses were 100, 300 and 1000 mg/kg bw/day, based on toxicity results from a 14-day dose range-finding study.
The following observations and examinations were evaluated: mortality / viability, clinical signs (daily), functional observations and locomotor activity (end of treatment), body weight and food consumption (at least at weekly intervals), clinical pathology (end of treatment), macroscopy at termination, organ weights and histopathology on a selection of tissues. In addition, the following reproduction/developmental parameters were determined: mating, fertility and conception indices, precoital time, number of corpora lutea and implantation sites, gestation index and duration, parturition, maternal care, sex ratio and early postnatal pup development (mortality, clinical signs, body weights, sex and macroscopy). Formulations were analysed once during the study to assess accuracy and homogeneity.
No treatment-related effects on systemic toxicity or reproductive parameters were observed in any of the test animals and it was concluded that the NOAEL for parental toxicity and reproductive effects was greater than 1000 mg/kg bw.
Effects on developmental toxicity
Description of key information
In the combined 28-day repeated dose toxicity study with the reproduction/ developmental toxicity screening test, the reported NOAEL for maternal toxicity and developmental/ teratogenic effects was greater than 1000 mg/kg bw. No treatment-related changes were observed in any of the test animals.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In the combined 28-day repeated dose toxicity study with the reproduction/ developmental toxicity screening test,1,1,1,3,5,5,5-heptamethyl-3-octyltrisiloxane was tested according to OECD TG 422 and in compliance with GLP (Charles River, 2016).
The test item,1,1,1,3,5,5,5-heptamethyl-3-octyltrisiloxane, was formulated in dried and deacidified corn oil and administered orally (gavage) to 10 male and 10 female rats per group. An extra 5 animals per sex in the control and high dose group were included and allowed 14 days of recovery. All the animals were treated daily, for at least 28 days. Main males and recovery males were exposed to the test substance for 29 days. Main females were treated for 41 to 47 days. Recovery females were exposed for 43 days. The selected doses were 100, 300 and 1000 mg/kg bw/day, based on toxicity results from a 14-day dose range-finding study.
The following observations and examinations were evaluated: mortality / viability, clinical signs (daily), functional observations and locomotor activity (end of treatment), body weight and food consumption (at least at weekly intervals), clinical pathology (end of treatment), macroscopy at termination, organ weights and histopathology on a selection of tissues. In addition, the following reproduction/developmental parameters were determined: mating, fertility and conception indices, precoital time, number of corpora lutea and implantation sites, gestation index and duration, parturition, maternal care, sex ratio and early postnatal pup development (mortality, clinical signs, body weights, sex and macroscopy). Formulations were analysed once during the study to assess accuracy and homogeneity.
No treatment-related effects on development were observed in any of the test animals and it was concluded that the NOAEL for maternal toxicity and developmental effects was greater than 1000 mg/kg bw.
Justification for classification or non-classification
Based on the available data for1,1,1,3,5,5,5-heptamethyl-3-octyltrisiloxane, no classification is required for reproductive or developmental toxicity according to Regulation (EC) No. 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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