Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-881-3 | CAS number: 17955-88-3
Endpoint summary
Administrative data
Description of key information
In the key skin sensitisation study, conducted according to OECD TG 406 and in compliance with GLP, the test substance, 1, 1, 1, 3, 5, 5, 5-heptamethyl-3-octyltrisiloxane, was reported to be not sensitising to the skin of guinea pigs (Eurofins, 2016).
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In the key skin sensitisation study, conducted according to OECD TG 406 and in compliance with GLP, the test substance, 1, 1, 1, 3, 5, 5, 5-heptamethyl-3-octyltrisiloxane, was reported to be not sensitising to the skin of guinea pigs (Eurofins, 2016).
At induction, 0.5 ml of undiluted test material was applied topically onto the skin of the right flanks of 20 guinea pigs for 6 hours under occlusive dressing. Three applications were performed at weekly intervals for three weeks. An empty Hill Top Chamber was applied to the test area of the negative control animals. The same procedure was used for both test and negative control groups.
At challenge, 14 days after the last induction application 0.5 ml of 0.75% test substance in acetone was applied on the right flank of test and negative control animals for 6 hours under occlusive dressing. Simultaneously, 0.5 ml of acetone was applied on the left flank of both test and negative control group animals for 6 hours under occlusive dressing. Approximately 24 and 48 hours after removal of the test item the skin reactions were observed and recorded. All animals were observed for signs of toxicity daily throughout the study period. Body weights were recorded prior to the first application and at the end of the observation period.
No mortality occurred during the study period. Neither erythema nor oedema were observed in any of the animals at any time of observation. There was no evidence of sensitisation in any of the animals.
Two supporting skin sensitisation studies, conducted according to OECD TG 406 and in compliance with GLP, were also available and reported the test item to be not sensitising to guinea pig skin (WIL Research, 1999; Aventis, 2001).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data for 1,1,1,3,5,5,5-heptamethyl-3-octyltrisiloxane, no classification is required for sensitisation according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
