Ethyltriphenylphosphonium iodide

Endpoint summary

Description of key information

not sensitising (OECD429/EU B.42, GLP, read across from structural analogue)

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records

Reference

Endpoint:

skin sensitisation: in vivo (LLNA)

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substance have similar skin sensitising properties because they share structural similarities with common functional groups: the organic moiety is the same - Ethyltriphenylphosphonium-ion -, the source substance has bromide as counter ion, the target substance iodide

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)

Source Target
Name Ethyltriphenylfosfonium bromide Ethyltriphenylphosphonium iodide
CAS 1530-32-1 4736-60-1
EC 216-223-3 225-245-2
Common functional group Ethyltriphenylphosphonium ion Ethyltriphenylphosphonium ion
Deviating functional group counter ion bromide counter ion iodide
Water solubility 89.2 g/L 7.84 g/L
Purity Please refer to section ´Confidential details in general comparable to source substance
on test material´ of the respective source substance ID.


3. ANALOGUE APPROACH JUSTIFICATION
The read-across hypothesis is based on the assumption that source and target do have comparable sensitising activity. Source and target are both Ethyltriphenylphosphonium salts with an identical organic moiety, the Ethyltriphenylphosphonium-ion. Source and target deviate only in their counterions - the source substance has bromide as counter ion, the target substance iodide. As source and target do have an identical organic moiety, and the counter ions are not associated with a sensitising activity, this read across is justified.

Reason / purpose for cross-reference:

read-across source

Key result

Parameter:

SI

Value:

1

Test group / Remarks:

1%

Key result

Parameter:

SI

Value:

1

Test group / Remarks:

2.5%

Parameter:

SI

Test group / Remarks:

5%

Remarks on result:

not measured/tested

Remarks:

due to mortality/toxicity (refer to 'Any other information on results')

Interpretation of results:

GHS criteria not met

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information:

Read-across data used. The read-across hypothesis is based on the assumption that source and target do have comparable sensitising activity. Source and target are both Ethyltriphenylphosphonium salts with an identical organic moiety, the Ethyltriphenylphosphonium-ion. Source and target deviate only in their counterions - the source substance has bromide as counter ion, the target substance iodide. As source and target do have an identical organic moiety, and the counter ions are not associated with sensitising activity, this read across is justified.

In an in vivo dermal sensitisation study (Local Lymph Node assay according to EU Method B.42 (2004), OECD guideline 429 (2002) and EPA OPPTS 870.2600(2003)), source substance Ethyltriphenylfosfonium bromide revealed no sensitising activity. Because of this result, Etyltriphenylphosphonium iodide in all probability has also no sensitising activity.

Justification for classification or non-classification

In an in vivo dermal sensitisation study (Local Lymph Node assay) Ethyltriphenylfosfonium bromide revealed no sensitising activity.

As Ethyltriphenylfosfonium bromide and Ethyltriphenylphosphonium iodide do have an identical organic moiety and the counter ions bromide and iodide are not associated with sensitising activity, Etyltriphenylphosphonium iodide in all probability has also no sensitising activity.

According to the criteria of REGULATION (EC) No 1272/2008, Ethyltriphenylphosphonium iodide does not have to be classified and has no obligatory labelling requirement for sensitization by skin contact.

According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2004), Ethyltriphenylphosphonium iodide does not have to be classified for sensitization by skin contact.

Ethyltriphenylphosphonium iodide is not classified for respiratory sensitisation because of lack of data.