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EC number: 225-245-2 | CAS number: 4736-60-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
48h-ErC50 and NOEC for green algae (Pseudokirchneriella subcapitata): 18 mg/L and 1.69 mg/L, respectively (OECD201/EU C.3, GLP, read across from structural analogue)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 18 mg/L
- EC10 or NOEC for freshwater algae:
- 1.69 mg/L
Additional information
The read-across hypothesis is based on the assumption that source and target do have comparable toxicity to aquatic algae. Source and target are both Ethyltriphenylphosphonium salts with an identical organic moiety, the Ethyltriphenylphosphonium-ion. Source and target deviate only in their counterions - the source substance has bromide as counter ion, the target substance iodide. However, source substance as well as target substance are soluble in water. When disolved, the organic moiety and the counter ions act individually. The counter ions bromide and iodide are not associated with toxicity to aquatic algae leading to classification. Thus, intrinsic toxicity to aquatic algae is determined by the organic moiety only. As source and target do have an identical organic moiety, this read across is justified.
The 48-hr-acute toxicity of source Ethyltriphenylfosfonium bromide to Pseudokirchneriella subcapitata was studied under static conditions according to OECD Guideline 201 (adopted March 23, 2006), EU Method C.3 (December 1992) and ISO International Standard 8692 (October 2004). Exponentially growing cultures were exposed to a control and Ethyltriphenylfosfonium bromide concentrations of 0.60, 1.5, 3.8, 9.5, 24 and 60 mg/L. Test concentrations were based on the result of a preceding range-finding test. The total test period was 48 hours and the initial algal cell density was 104 cells/mL. Samples for determination of actual exposure concentrations were taken at the start, after 24 and 48 hours of exposure. Analyses showed that measured concentrations were in agreement with nominal throughout the 48-hour test period (97-104%).
Ethyltriphenylfosfonium bromide reduced growth rate and inhibited the yield of this fresh water algae species significantly at 3.8 mg/L and higher.
The EC50 for growth rate reduction (ErC50: 0-48h) was 16 mg/L with a 95 % confidence interval ranging from 9.8 to 25 mg/L.
The EC50 for yield inhibition (EyC50: 0-48h) was 4.3 mg/L with a 95 % confidence interval ranging from 3.1 to 6.1 mg/L.
The NOEC for both growth rate reduction and yield inhibition was 1.5 mg/L.
ErC50 Ethyltriphenylphosphonium iodide: 18 mg/L, recalculated from effect concentration of source substance in consideration of different molecular weights
NOEC Ethyltriphenylphosphonium iodide: 1.69 mg/L, recalculated from effect concentration of source substance in consideration of different molecular weights
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