Ethyltriphenylphosphonium iodide

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Reference 2

Reference Type:

secondary source

Title:

Unnamed

Year:

1992

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

other: US Federal Hazardous Substances Control Act

Version / remarks:

Code of Federal Regulations, Titel 16, Chapter II, 1977

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Version / remarks:

2002

GLP compliance:

no

Remarks:

study performed prior to implementation of GLP

Test material

Test material information

Constituent 1

Reference substance name:

Ethyltriphenylphosphonium iodide

EC Number:

225-245-2

EC Name:

Ethyltriphenylphosphonium iodide

Cas Number:

4736-60-1

Molecular formula:

C20H20IP

IUPAC Name:

ethyltriphenylphosphonium iodide

Test material form:

solid: particulate/powder

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Albino rabbits (no further data)

Test system

Type of coverage:

occlusive

Preparation of test site:

other: shaved and shaved/abraded

Vehicle:

physiological saline

Controls:

no

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg
- Concentration (if solution): undiluted moistened with physiological saline

Duration of treatment / exposure:

24 h

Observation period:

72 h
Reading time points: 24 and 72 h

Number of animals:

6

Details on study design:

TEST SITE
- Area of exposure: Patch test on shaved and shaved/abraded skin.
- Type of wrap if used: occlusive

REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes

SCORING SYSTEM: Draize scoring system

Five-tenths gram of each undiluted sample which was moistered with physiological saline to form a paste was applied under one inch-square surgical gauze patch, two layers thick, to an intact skin area and an abraded skin area on each of six albino rabbits. The application sites were prepared by clipping the hair from the saddle area of the rabbits. The abraded areas were prepared by making minor epidermal incisions with a hypodermic needle. The abrasions were sufficiently deep to penetrate the epidermis but not to induce bleeding. Each patch was held in place with two strips of one-inch adhesive tape. After application of the patches, the trunk of each rabbit was wrapped with rubber which was secured with staples. An outer layer of gauze and tape was placed around the trunk of the animals. The animals were restrained in Newmann harnesses for 24 hours.
At the end of the 24-hour exposure period, the patches were removed and the residual sample was gently removed from the skin with a moistened towed. The reactions were scored immediately after removal of the patches (24-hour reading), and again two days later (72-hour reading). The scoring system used is identical to the scoring system of OECD guideline 404 (version 2002).

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

animal: 6/6

Time point:

other: 24, 72 h

Score:

0

Max. score:

4

Remarks on result:

other: intact as well as abraded skin

Results 2

Irritation parameter:

edema score

Basis:

animal: 6/6

Time point:

other: 24, 72 h

Score:

0

Max. score:

4

Remarks on result:

other: intact as well as abraded skin

Irritant / corrosive response data:

No irritation or corrosive effects were noted at either the 24 or 72 hour reading.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

No skin irritation was caused by 24 hours occlusive exposure to Ethyltriphenylphosphonium iodide.
According to the criteria of REGULATION (EC) No 1272/2008, Ethyltriphenylphosphonium iodide does not have to be classified and has no obligatory labeling requirement for skin irritation.
According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations, Ethyltriphenylphosphonium iodide does not have to be classified for skin irritation.