Registration Dossier
Registration Dossier
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EC number: 202-992-2 | CAS number: 101-96-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Very concise test report, no information on test protocol available.
- Justification for type of information:
- No study was selected since weight of evidence approach was applied.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Inhalation toxiticy test with an exposure of 6 hours.
- GLP compliance:
- no
- Remarks:
- Study performed in 1976
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- N,N'-di-sec-butyl-p-phenylenediamine
- EC Number:
- 202-992-2
- EC Name:
- N,N'-di-sec-butyl-p-phenylenediamine
- Cas Number:
- 101-96-2
- Molecular formula:
- C14H24N2
- IUPAC Name:
- N,N'-di-sec-butyl-p-phenylenediamine
- Details on test material:
- - Name: Santoflex 44
- Lot n°: 274777
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- Sample temperature: ambient
Chamber temperature: 27°C
Chamber humidity: 80%
Chamber volume: 35L
Air flow rate: 4.0 L/min
Initial sample: 69.1 g
Recovered sample: 68.7 g
Condensed sample: 0.0 g
Vaporized sample: 0.4 g - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- 0.2 mg/L
- No. of animals per sex per dose:
- 6 males
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 0.2 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- no mortalities
- Clinical signs:
- other: no toxic signs
- Other findings:
- Viscera appeared normal in survivors (14d).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
