Registration Dossier
Registration Dossier
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EC number: 216-378-7 | CAS number: 1569-69-3
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence
Cyclohexylmercaptan was not readily biodegradable (0% degradation in 28 days) in a standard test conducted according to OECD 301F (Youngs, 2009); no other biodegradation data are available. It does not contain any functional groups that are susceptible to hydrolysis and no data are available on other abiotic degradation mechanisms. The substance therefore meets the screening criteria for persistence (P or vP) according to REACH Technical Guidance Chapter R.11.
Bioaccumulation
Cyclohexylmercaptan has a measured log log Kow of 3.7, determined in a study conducted according to OECD 117 (Baltussen, 2013). No measured bioaccumulation data are available. The substance does not meet the screening criteria for B or vB according to REACH Technical Guidance Chapter R.11.
Toxicity
Acute aquatic toxicity data are available for invertebrates and algae. The lowest measured EC50 is 0.43 mg/l for algae, determined in a test conducted according to OECD 202 (Harlan Laboratories Ltd, 2009b). The 72-hour NOEC in this study was 0.15 mg/l. No other chronic ecotoxicity data are available. On the basis of the available measured data, cyclohexylmercaptan does not meet the screening criteria for toxicity (T) for the environment, according to REACH Technical Guidance Chapter R.11.
Based on the limited dataset that is currently available, cyclohexylmercaptan is not classified for carcinogenicity, mutagenicity, reproductive toxicity or specific target organ toxicity following repeated exposures. Additional toxicological testing is not warranted for this substance based on the relevant REACH Annex requirements. On the basis of the available information the substance does not meet the criteria for toxicity for mammalian effects according to REACH Technical Guidance Chapter R.11.
Overall conclusions
Cyclohexylmercaptan may be persistent in the environment but it is not bioaccumulative or toxic according to the criteria set out in REACH Technical Guidance Chapter R.11. It is therefore not considered to be PBT or vPvB.
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