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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically acceptable data

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993

Materials and methods

Principles of method if other than guideline:
other: no data
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Bronopol, no further data provided.

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
The test was conducted with a freshly prepared aqueous solution of bronopol and with a solution containing the decomposition products of bronopol. The latter solution was obtained by maintaining an aqueous 1% solution of bronopol (pH 7 - 7.5) at 100 °C for one hour. Both test solutions were tested at the same concentrations, and each test group comprised 2 mice. The mice were observed for mortality.
Doses:
5, 10, 20, 40, 80, 160 and 320 mg/kg bw
No. of animals per sex per dose:
2

Results and discussion

Any other information on results incl. tables

Mortality: 
----------
________________________________________________
Dose (mg/kg) / Bronopol / Degraded bronopol
------------------------------------------------
5 / 0/2 / 0/2
------------------------------------------------
10 / 0/2 / 0/2
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20 / 1/2 / 0/2
------------------------------------------------
40 / 1/2 / 0/2
------------------------------------------------
80 / 2/2 / 0/2
------------------------------------------------
160 / 2/2 / 0/2
------------------------------------------------
320 / 2/2 / 0/2
________________________________________________

Applicant's summary and conclusion