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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

The acute toxicity of 4-methylthiosemicarbazide was evaluated with Daphnia magna in a study performed in accordance with OECD testing guideline 202 (part I) and GLP requirements. EC50-48 h was estimated using measured concentrations (geometric mean) as being equal to 3.1 mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
3.1 mg/L

Additional information

The acute toxicity of 4-methylthiosemicarbazide was evaluated with Daphnia magna in a study performed in accordance with OECD testing guideline 202 (part I) and GLP requirements.

The young daphnids were exposed to nominal test concentrations between 0.78 and 50 mg/L under static conditions during 48 hours. The mean measured concentrations were maintained between 80 and 120 % of nominal concentration from the 3.13 mg/L concentration only. EC50-48 h was estimated using measured concentrations (geometric mean) as being equal to 3.1 mg/L.

Mortality in control, temperatures, pH range and dissolved oxygen concentration were reported and in agreement with the guideline requirements.