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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The acute toxicity of 4-methyl-3-thiosemicarbazide was evaluated with Danio rerio: LC50-96 h was estimated using measured concentrations as being equal to 20 mg/L.

Key value for chemical safety assessment

LC50 for freshwater fish:
20 mg/L

Additional information

The acute toxicity of 4-methyl-3-thiosemicarbazide was evaluated with Danio rerio in a study performed in accordance with OECD testing guideline 203 and GLP requirements.

The fish were exposed to nominal test concentrations between 5.08 and 50 mg/L under static conditions during 96 hours. The mean measured concentrations were maintained between 80 and 120 % of nominal. LC50-96 h was estimated using measured concentrations as being equal to 20 mg/L.

No other clinical signs were observed.

Mortality in control, temperatures, pH range and dissolved oxygen concentration were reported and in agreement with the guideline requirements.