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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

The determination of the growth inhibition of the freshwater algae Pseudokirchneriella subcapitata exposed to the test item 4-methyl-3-thiosemicarbazide for a duration of 72 hours was assessed according to the OECD Guideline 201. ErC50-72h was determined as 30 mg/L
 

Key value for chemical safety assessment

EC50 for freshwater algae:
30 mg/L
EC10 or NOEC for freshwater algae:
18 mg/L

Additional information

The determination of the growth inhibition of the freshwater algae Pseudokirchneriella subcapitata (previously known as Raphidocelis subcapitata and Selenastrum capricornutum) exposed to the test item 4-methyl-3-thiosemicarbazide for a duration of 72 hours was assessed according to the OECD Guideline 201.

Algae were exposed to 1 to 100 mg

4-methyl-3-thiosemicarbazide

/L dissolved in dilution water. The concentrations of test item causing a 50% reduction in biomass (EbC50) and in growth rate (ErC50) were estimated over a time period of 72 hours. The results were as follows:

 

 

Endpoint

EC50-72h, mg/L

(95%CI)

EC10-72h, mg/L

Cell growth – Biomass (b)

26 (ND)

15 (ND)

Growth rate – Cell multiplication (r)

30 (13 – 75)

18 (2.9-32)

CI: confidence interval; ND: not determined