Registration Dossier
Registration Dossier
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EC number: 260-330-8 | CAS number: 56677-60-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetradecyl chloroformate
- EC Number:
- 260-330-8
- EC Name:
- Tetradecyl chloroformate
- Cas Number:
- 56677-60-2
- Molecular formula:
- C15H29ClO2
- IUPAC Name:
- tetradecyl carbonochloridate
- Details on test material:
- - Name of test material (as cited in study report): Myristylchlorformiat
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Firma Gaukler
- Weight at study initiation: 2.45 - 3.10 kg
- Housing: individually
- Diet: ca. 130 g per animal/day
- Water: ca. 250 ml per animal/day
- Acclimation period: at leat 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 8 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: upper third of the back or flanks
- % coverage: 2.5 cm x 2.5 cm
- Type of wrap if used: occlusive, no further data
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with lutrol and lutrol/water (1:1)
- Time after start of exposure: 4 hours
SCORING SYSTEM: as described in OECD guideline 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- 2.67
- Reversibility:
- not fully reversible within: 8 days in 1/3 animals (grade 1)
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- 1.33
- Reversibility:
- fully reversible within: 8 days
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Conclusions:
- Tetradecyl chloroformate was found to be irritating to the skin.
- Executive summary:
After application of the test substance to the skin of rabbits, the mean value (24, 48 and 72 h) of the scores of either erythema or edema formation was calculated over all animals tested or for each animal individually.
The mean value for erythema formation was 2.67 (individual animals 2.33, 2.67, and 3.0) over all animals tested.
The mean value for edema formation was 1.33 over all animals tested.The substance is therefore classified as irritating to skin according to EU criteria and as irritating cat. 2 according to GHS criteria.
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