Registration Dossier
Registration Dossier
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EC number: 202-044-8 | CAS number: 91-15-6
Endpoint summary
Administrative data
Description of key information
O-phthalonitrile is considered as non-irritating to the skin and the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation was tested using an internal standard method (BASF test). This study meets scientific standards with acceptable restrictions (limited documentation).Whiterabbits were used. 2 animals were treated for 1, 5 and 15 minutes and for 20 hours using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the test substance. The test substance induced questionable erythema after 20 h occlusive exposure in 1/2 animals, which was reversible within 4 d. 15 min exposure did not cause any irritation effects.
Eye irritation was examined in a study comparable to OECD Guideline 405 with acceptable restrictions (limited documentation, reduced application volume). The study is however sufficient for evaluation of this endpoint. Irritation effects were not observed after 24 and 48 h. Equivalent effects to the talcum-treated eyes were observed on the day of application.
Justification for classification or non-classification
No classification suggested for irritation as criteria of regulation 1272/2008/EC are not met.
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