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EC number: 500-078-0 | CAS number: 31923-84-9 1 - 4.5 moles propoxylated
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Apr - 13 May 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Ministerium für Arbeit, Gesundheit und Soziales des Landes Nordrhein-Westfalen, Düsseldorf, Germany
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Ethane- 1,2-diol, propoxylated
- EC Number:
- 500-078-0
- EC Name:
- Ethane- 1,2-diol, propoxylated
- Cas Number:
- 31923-84-9
- Molecular formula:
- HO(C3H6O)nC2H4(C3H6)nOH sum of n: >1 - <4.5 mol PO
- IUPAC Name:
- Ethane-1,2-diol, propoxylated
- Details on test material:
- - Physical state: liquid
- Content: 100%
- molecular weight: approx. 235
- Stability under test conditions: analytically approved
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- HsdCpb:Wu
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: demineralized water
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- other: LD50 cut-off
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no deaths
- Clinical signs:
- other: piloerection, decreased motility, closed eyelids, hunched posture, narrowed palpebral fissure, poor reflexes, poor general condition, uncoordinated gait and abdominal and lateral position
- Gross pathology:
- no findings
- Other findings:
- none
Any other information on results incl. tables
| Dose (mg/kg bw) | Toxicological results | Onset and duration of clinical signs | Onset of mortality |
| (1st) 2000 | 0 / 3/ 3 | 15´- 6h | --- |
| (2nd) 2000 | 0 / 3/ 3 | 15´- 6h | --- |
Toxicological results:
number of dead animals / number of animals with clinical signs after treatment / number of animals treated
Additional detailed tables are attached below under 'Attached background material'.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
- Conclusions:
- According to OECD guideline 423 the LD50 cut-off of 5000 mg/kg bw.
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