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EC number: 500-078-0
CAS number: 31923-84-9
1 - 4.5 moles propoxylated
"ETHANE-1,2-DIOL, PROPOXYLATED, 1-4.5 MOL PROPOXYLATED
(CAS31923-84-9; EU NLP 500-078-0)AND2,2’-OXYDIETHANOL, PROPOXYLATED,
1-4.5 MOL PROPOXYLATED (CAS9051-51-8; EU NLP 500-031-4)
These two core substances are so
closely related structurally that they are best examined together.
There are no experimental studies on
the toxicokinetics of propoxylated ethane-1,2-diol or propoxylated
2,2’-oxydiethanol. The toxicokinetics of the core substances and the
repeating unit are summarised in Illing and Barratt (2007 revised 2009).
Both core substances have two free hydroxy groups, thus NLP polyols are
likely to consist predominantly of chains of between one and two
repeating units, with some chains containing three repeating units.
For the calculations
of bioavailability of the commercial NLP polyol, logP values were
calculated using the incremental fragment method of Suzuki and Kudo
(1990). The propoxy groups have an important effect on the toxicity by
modulating any toxicity arising from the core substance. The
substitution of a hydroxyl group on a core compound by a propoxy group
increases its logP value by 0.24 units and its molecular weight by 58Daltons. The
combined effect of these changes is to reduce the bioavailability by a
factor of 1.53 (calculated
using the Potts and Guy equation). MEG + 3PO indicates the component
representing the mean toxicity."
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