Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result:

"POSTULATED TOXICOKINETICS FOR THE NEW NLP POLYOLS INTRODUCTION

The oligomers on the EU list of NLP polyols cover a range of propoxylated materials, containing several repeating units attached to the core substance. In practice commercial material does not consist of a single substance, and a range of oligomers are likely to be present in the commercial material tested for toxicity. In order to reconcile these differences, the ‘type’ NLP polyol, representing the contribution of all of the components in the commercial material used for toxicity testing, has been determined using structure-activity information and information on the composition of the commercial material tested. The bases of the toxicokinetics assessments are given in this part of the report." (cited from Illing, H P A, Barratt, M D (2010). Grouping of Additional NLP ‘Polyols’ and their Toxicokinetics Assessments. Confidential report to the REACH Centrum July 2010)

Key value for chemical safety assessment

Additional information

"ETHANE-1,2-DIOL, PROPOXYLATED, 1-4.5 MOL PROPOXYLATED (CAS31923-84-9; EU NLP 500-078-0)AND2,2’-OXYDIETHANOL, PROPOXYLATED, 1-4.5 MOL PROPOXYLATED (CAS9051-51-8; EU NLP 500-031-4)

  

These two core substances are so closely related structurally that they are best examined together.

 

There are no experimental studies on the toxicokinetics of propoxylated ethane-1,2-diol or propoxylated 2,2’-oxydiethanol. The toxicokinetics of the core substances and the repeating unit are summarised in Illing and Barratt (2007 revised 2009). Both core substances have two free hydroxy groups, thus NLP polyols are likely to consist predominantly of chains of between one and two repeating units, with some chains containing three repeating units." (cited from Illing, H P A, Barratt, M D (2010). Grouping of Additional NLP ‘Polyols’ and their Toxicokinetics Assessments. Confidential report to the REACH Centrum July 2010)

Discussion on bioaccumulation potential result:

"ETHANE-1,2-DIOL, PROPOXYLATED, 1-4.5 MOL PROPOXYLATED (CAS31923-84-9; EU NLP 500-078-0)AND2,2’-OXYDIETHANOL, PROPOXYLATED, 1-4.5 MOL PROPOXYLATED (CAS9051-51-8; EU NLP 500-031-4)

  

These two core substances are so closely related structurally that they are best examined together.

 

There are no experimental studies on the toxicokinetics of propoxylated ethane-1,2-diol or propoxylated 2,2’-oxydiethanol. The toxicokinetics of the core substances and the repeating unit are summarised in Illing and Barratt (2007 revised 2009). Both core substances have two free hydroxy groups, thus NLP polyols are likely to consist predominantly of chains of between one and two repeating units, with some chains containing three repeating units." (cited from Illing, H P A, Barratt, M D (2010). Grouping of Additional NLP ‘Polyols’ and their Toxicokinetics Assessments. Confidential report to the REACH Centrum July 2010)