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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

The chronic toxicity of Propylidynetrimethanol, ethoxylated to aquatic invertebrates (Daphnia magna) was tested according to OECD 202. No toxic effects against D. magna was observed during 21 days exposure up to a concentration of 10 mg/L; NOEC >= 10 mg/L (Currenta, 2009).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
10 mg/L

Additional information

Chronic toxicity of the structurally related analogue D-Glucitol (Sorbitol), propoxylated (CAS 52625-13-5) to invertebrates has been investigated in a reproduction test with Daphnia magna following the OECD guideline 211 using semi-static exposure. No effects were observed at the maximum concentration test (10 mg/l) and the NOEC are reported at 10 mg/l (nominal) for reproduction and mortality. Exposure concentrations were verified by mean of HPLC-MSD and were ranging between 73.3 and 100% of the nominal concentrations.

Hypothesis for the read-across approach:

Group: Succhrose, propoxylated; Propylidynetrimethanol, propoxylated; Glycerol, propoxylated; D‑Glucitol, propoxylated; Propane-1,2-diol, propoxylated; Pentaerythritol, propoxylated; 2,2',2''‑Nitrilotriethanol, propoxylated; Trimethylolpropane, ethoxylated; Diethylene glycol, propoxylated; Ethylene glycol, propoxylated; Diethanolamine, propoxylated.

The substance is member of a group of chemicals with similar chemical structure and physical behaviour:

1.) Chemical similarity: All of these substances have terminal OH-groups and ether-linkages as common structural features. Thus, the substances differ from each other only in the identity/type of starter molecule (aliphatic alcohols with 2 to 8 hydroxy functions) used and its associated bonding with the alkoxylate repeating units. Typically the products are substances with a range of Ethyleneoxide or Propyleneoxide units (1 -12.5) added to starter molecules. All substances are characterised by a molecular weight distribution of ca. 150 - 1000. The common function of the members of the group is to allocate a high number of hydroxy functions which are intended to react with e.g. an isocyanate.

2.) Physical behaviour: All members of the group are liquids with elevated viscosity, high solubility in water (> 100 g/L) and a low vapour pressure (<10E-04 hPa).