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EC number: 242-060-2
CAS number: 18172-67-3
Table 1: Micronucleus assay - Summary table
Erythrocytes with micronuclei
of polychromatic erythrocytes (PCEs) and normochromatic erythrocytes
(NCEs) = 1000; I = within the normal range; - = no difference from
control (P > 0.5); * = significantly different from control (P < 0.05);
A = outside the normal range
a bone marrow micronucleus test, performed according to GLP and OECD
guideline 474, NMRI mice (5/sex/dose) were given a single oral (gavage)
dose of camphene in sesame oil at concentrations of 0 and 4000 mg/kg bw.
Bone marrow was extracted after 24, 48 or 72 hours of exposure and the
prepared slides were scanned to determine the number of polychromatic
erythrocytes (PCEs) with micro nuclei per 1000 PCEs and number of
normochromatic erythrocytes (NCEs) with micronuclei per 1000 NCEs per
animal. In addition, PCE:NCE ratio was determined. A preliminary
range-finding test was also conducted in which heavy clinical symptoms
were observed in male and female mice at 5000 mg/kg bw.
control (cyclophosphamide, 50 mg/kg bw) induced a marked and
statistically significant increase of the number of polychromatic
erythrocytes with micronuclei in both males and females indicating the
sensitivity of the test system. No statistically significant increases
in the frequency of micronucleated PCEs or NCEs and PCE:NCE ratios were
observed at any dose levels with camphene.
the test conditions, camphene is not considered as mutagenic in the
mouse bone marrow micronucleus test according to Directive 67/548/EEC
and CLP Regulation (EC) No 1272/2008.
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